Frøhlich R - Search Results

1

Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.

Andersen MB, Tesauro C, Gonzalez M, Kristoffersen EL, Alonso C, Rubiales G, Coletta A, Frøhlich R, Stougaard M, Ho YP, Palacios F, Knudsen BR. Andersen MB, et al. Among authors: frohlich r. Nanoscale. 2017 Feb 2;9(5):1886-1895. doi: 10.1039/c6nr06848k. Nanoscale. 2017. PMID: 28094391

2

Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations.

Kristoffersen EL, Jørgensen LA, Franch O, Etzerodt M, Frøhlich R, Bjergbæk L, Stougaard M, Ho YP, Knudsen BR. Kristoffersen EL, et al. Among authors: frohlich r. Nanoscale. 2015 Jun 7;7(21):9825-34. doi: 10.1039/c5nr01474c. Nanoscale. 2015. PMID: 25963854

3

Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor.

Jensen PW, Falconi M, Kristoffersen EL, Simonsen AT, Cifuentes JB, Marcussen LB, Frøhlich R, Vagner J, Harmsen C, Juul S, Ho YP, Withers MA, Lupski JR, Koch J, Desideri A, Knudsen BR, Stougaard M. Jensen PW, et al. Among authors: frohlich r. Biosens Bioelectron. 2013 Oct 15;48:230-7. doi: 10.1016/j.bios.2013.04.019. Epub 2013 Apr 25. Biosens Bioelectron. 2013. PMID: 23693093

4

Topoisomerase I as a biomarker: detection of activity at the single molecule level.

Proszek J, Roy A, Jakobsen AK, Frøhlich R, Knudsen BR, Stougaard M. Proszek J, et al. Among authors: frohlich r. Sensors (Basel). 2014 Jan 10;14(1):1195-207. doi: 10.3390/s140101195. Sensors (Basel). 2014. PMID: 24434877 Free PMC article.

5

Microfluidics-Enabled Enzyme Activity Measurement in Single Cells.

Tesauro C, Frøhlich R, Stougaard M, Ho YP, Knudsen BR. Tesauro C, et al. Among authors: frohlich r. Methods Mol Biol. 2015;1346:209-19. doi: 10.1007/978-1-4939-2987-0_14. Methods Mol Biol. 2015. PMID: 26542724

6

Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation.

Keller JG, Hymøller KM, Thorsager ME, Hansen NY, Erlandsen JU, Tesauro C, Simonsen AKW, Andersen AB, Vandsø Petersen K, Holm LL, Stougaard M, Andresen BS, Kristensen P, Frøhlich R, Knudsen BR. Keller JG, et al. Among authors: frohlich r. Nucleic Acids Res. 2022 Jun 24;50(11):6332-6342. doi: 10.1093/nar/gkac482. Nucleic Acids Res. 2022. PMID: 35687110 Free PMC article.

7

Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding.

Frøhlich RF, Andersen FF, Westergaard O, Andersen AH, Knudsen BR. Frøhlich RF, et al. J Mol Biol. 2004 Feb 6;336(1):93-103. doi: 10.1016/j.jmb.2003.12.007. J Mol Biol. 2004. PMID: 14741206

8

Recombinogenic flap ligation mediated by human topoisomerase I.

Andersen FF, Andersen KE, Kusk M, Frøhlich RF, Westergaard O, Andersen AH, Knudsen BR. Andersen FF, et al. Among authors: frohlich rf. J Mol Biol. 2003 Jul 4;330(2):235-46. doi: 10.1016/s0022-2836(03)00593-x. J Mol Biol. 2003. PMID: 12823964

9

Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification.

Tesauro C, Juul S, Arnò B, Nielsen CJ, Fiorani P, Frøhlich RF, Andersen FF, Desideri A, Stougaard M, Petersen E, Knudsen BR. Tesauro C, et al. Among authors: frohlich rf. Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:2416-9. doi: 10.1109/EMBC.2012.6346451. Annu Int Conf IEEE Eng Med Biol Soc. 2012. PMID: 23366412

10

Inhibition of Flp recombinase by the topoisomerase I-targeting drugs, camptothecin and NSC-314622.

Frøhlich RF, Hansen SG, Lisby M, Grainge I, Westergaard O, Jayaram M, Knudsen BR. Frøhlich RF, et al. J Biol Chem. 2001 Mar 9;276(10):6993-7. doi: 10.1074/jbc.C000901200. Epub 2001 Jan 10. J Biol Chem. 2001. PMID: 11152668 Free article.

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