Frédérick R - Search Results

1

Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments.

Spillier Q, Ravez S, Dochain S, Vertommen D, Thabault L, Feron O, Frédérick R. Spillier Q, et al. Among authors: frederick r. Molecules. 2021 Jan 18;26(2):477. doi: 10.3390/molecules26020477. Molecules. 2021. PMID: 33477510 Free PMC article.

2

Synthesis and biological evaluation of di-aryl urea derivatives as c-Kit inhibitors.

Ravez S, Arsenlis S, Barczyk A, Dupont A, Frédérick R, Hesse S, Kirsch G, Depreux P, Goossens L. Ravez S, et al. Among authors: frederick r. Bioorg Med Chem. 2015 Nov 15;23(22):7340-7. doi: 10.1016/j.bmc.2015.10.035. Epub 2015 Oct 24. Bioorg Med Chem. 2015. PMID: 26526740

3

Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy.

Ravez S, Spillier Q, Marteau R, Feron O, Frédérick R. Ravez S, et al. Among authors: frederick r. J Med Chem. 2017 Feb 23;60(4):1227-1237. doi: 10.1021/acs.jmedchem.6b01167. Epub 2016 Dec 22. J Med Chem. 2017. PMID: 27959531 Review.

4

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).

Ravez S, Corbet C, Spillier Q, Dutu A, Robin AD, Mullarky E, Cantley LC, Feron O, Frédérick R. Ravez S, et al. Among authors: frederick r. J Med Chem. 2017 Feb 23;60(4):1591-1597. doi: 10.1021/acs.jmedchem.6b01166. Epub 2017 Jan 27. J Med Chem. 2017. PMID: 28085281 Free PMC article.

5

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.

Ameryckx A, Thabault L, Pochet L, Leimanis S, Poupaert JH, Wouters J, Joris B, Van Bambeke F, Frédérick R. Ameryckx A, et al. Among authors: frederick r. Eur J Med Chem. 2018 Nov 5;159:324-338. doi: 10.1016/j.ejmech.2018.09.067. Epub 2018 Sep 28. Eur J Med Chem. 2018. PMID: 30300845

6

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation.

Spillier Q, Vertommen D, Ravez S, Marteau R, Thémans Q, Corbet C, Feron O, Wouters J, Frédérick R. Spillier Q, et al. Among authors: frederick r. Sci Rep. 2019 Mar 18;9(1):4737. doi: 10.1038/s41598-019-41187-0. Sci Rep. 2019. PMID: 30894617 Free PMC article.

7

Structure-Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH).

Spillier Q, Ravez S, Unterlass J, Corbet C, Degavre C, Feron O, Frédérick R. Spillier Q, et al. Among authors: frederick r. Pharmaceuticals (Basel). 2020 Jan 22;13(2):20. doi: 10.3390/ph13020020. Pharmaceuticals (Basel). 2020. PMID: 31979167 Free PMC article.

8

Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides.

Thabault L, Brisson L, Brustenga C, Martinez Gache SA, Prévost JRC, Kozlova A, Spillier Q, Liberelle M, Benyahia Z, Messens J, Copetti T, Sonveaux P, Frédérick R. Thabault L, et al. Among authors: frederick r. J Med Chem. 2020 May 14;63(9):4628-4643. doi: 10.1021/acs.jmedchem.9b01955. Epub 2020 Apr 15. J Med Chem. 2020. PMID: 32250117

9

The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases.

Kentache T, Thabault L, Peracchi A, Frédérick R, Bommer GT, Van Schaftingen E. Kentache T, et al. Among authors: frederick r. Biosci Rep. 2020 Jun 26;40(6):BSR20200927. doi: 10.1042/BSR20200927. Biosci Rep. 2020. PMID: 32542330 Free PMC article.

10

Targeting protein self-association in drug design.

Thabault L, Liberelle M, Frédérick R. Thabault L, et al. Among authors: frederick r. Drug Discov Today. 2021 May;26(5):1148-1163. doi: 10.1016/j.drudis.2021.01.028. Epub 2021 Feb 3. Drug Discov Today. 2021. PMID: 33548462 Review.

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