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Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence.
Scott J, Sueiro-Olivares M, Thornton BP, Owens RA, Muhamadali H, Fortune-Grant R, Thomson D, Thomas R, Hollywood K, Doyle S, Goodacre R, Tabernero L, Bignell E, Amich J. Scott J, et al. Among authors: fortune grant r. mBio. 2020 Oct 13;11(5):e01985-20. doi: 10.1128/mBio.01985-20. mBio. 2020. PMID: 33051366 Free PMC article.
Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response.
Sueiro-Olivares M, Scott J, Gago S, Petrovic D, Kouroussis E, Zivanovic J, Yu Y, Strobel M, Cunha C, Thomson D, Fortune-Grant R, Thusek S, Bowyer P, Beilhack A, Carvalho A, Bignell E, Filipovic MR, Amich J. Sueiro-Olivares M, et al. Among authors: fortune grant r. PLoS Biol. 2021 Jun 1;19(6):e3001247. doi: 10.1371/journal.pbio.3001247. eCollection 2021 Jun. PLoS Biol. 2021. PMID: 34061822 Free PMC article.
Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms.
Rahman S, van Rhijn N, Papastamoulis P, Thomson DD, Carter Z, Fortune-Grant R, Rattray M, Bromley MJ, Bignell E. Rahman S, et al. Among authors: fortune grant r. Front Cell Infect Microbiol. 2022 Jul 28;12:907519. doi: 10.3389/fcimb.2022.907519. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35982778 Free PMC article.
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.
Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, Houlder E, Kowalski CH, Raj S, Paul S, Cook P, Parker JE, Kelly S, Cramer RA, Latgé JP, Moye-Rowley S, Bignell E, Bowyer P, Bromley MJ. Furukawa T, et al. Among authors: fortune grant r. Nat Commun. 2020 Jan 22;11(1):427. doi: 10.1038/s41467-019-14191-1. Nat Commun. 2020. PMID: 31969561 Free PMC article.
Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility.
Hwang SJ, Pardo DM, Zheng H, Bayguinov Y, Blair PJ, Fortune-Grant R, Cook RS, Hennig GW, Shonnard MC, Grainger N, Peri LE, Verma SD, Rock J, Sanders KM, Ward SM. Hwang SJ, et al. Among authors: fortune grant r. J Physiol. 2019 May;597(9):2337-2360. doi: 10.1113/JP277335. Epub 2019 Mar 28. J Physiol. 2019. PMID: 30843201 Free PMC article.
Functional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target.
van Rhijn N, Zhao C, Al-Furaji N, Storer I, Valero C, Gago S, Chown H, Baldin C, Fortune-Grant R, Shuraym HB, Ivanova L, Kniemeyer O, Krüger T, Bignell E, Goldman G, Amich J, Delneri D, Bowyer P, Brakhage A, Haas H, Bromley M. van Rhijn N, et al. Among authors: fortune grant r. Res Sq [Preprint]. 2023 May 30:rs.3.rs-2960526. doi: 10.21203/rs.3.rs-2960526/v1. Res Sq. 2023. PMID: 37398159 Free PMC article. Preprint.