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Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
Nat Commun. 2022 Jan 10;13(1):115. doi: 10.1038/s41467-021-27726-2.
Nat Commun. 2022.
PMID: 35013254
Free PMC article.
The chloramphenicol/H+ antiporter CraA of Acinetobacter baumannii AYE reveals a broad substrate specificity.
Foong WE, Tam HK, Crames JJ, Averhoff B, Pos KM.
Foong WE, et al.
J Antimicrob Chemother. 2019 May 1;74(5):1192-1201. doi: 10.1093/jac/dkz024.
J Antimicrob Chemother. 2019.
PMID: 30783664
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Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
Tam HK, Malviya VN, Foong WE, Herrmann A, Malloci G, Ruggerone P, Vargiu AV, Pos KM.
Tam HK, et al. Among authors: foong we.
J Mol Biol. 2020 Feb 14;432(4):861-877. doi: 10.1016/j.jmb.2019.12.025. Epub 2019 Dec 25.
J Mol Biol. 2020.
PMID: 31881208
Free PMC article.
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Tigecycline efflux in Acinetobacter baumannii is mediated by TetA in synergy with RND-type efflux transporters.
Foong WE, Wilhelm J, Tam HK, Pos KM.
Foong WE, et al.
J Antimicrob Chemother. 2020 May 1;75(5):1135-1139. doi: 10.1093/jac/dkaa015.
J Antimicrob Chemother. 2020.
PMID: 32049277
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Allosteric drug transport mechanism of multidrug transporter AcrB.
Tam HK, Foong WE, Oswald C, Herrmann A, Zeng H, Pos KM.
Tam HK, et al. Among authors: foong we.
Nat Commun. 2021 Jun 29;12(1):3889. doi: 10.1038/s41467-021-24151-3.
Nat Commun. 2021.
PMID: 34188038
Free PMC article.
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Binding of Tetracyclines to Acinetobacter baumannii TetR Involves Two Arginines as Specificity Determinants.
Sumyk M, Himpich S, Foong WE, Herrmann A, Pos KM, Tam HK.
Sumyk M, et al. Among authors: foong we.
Front Microbiol. 2021 Jul 19;12:711158. doi: 10.3389/fmicb.2021.711158. eCollection 2021.
Front Microbiol. 2021.
PMID: 34349752
Free PMC article.
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AI is a viable alternative to high throughput screening: a 318-target study.
Atomwise AIMS Program.
Atomwise AIMS Program.
Sci Rep. 2024 Apr 2;14(1):7526. doi: 10.1038/s41598-024-54655-z.
Sci Rep. 2024.
PMID: 38565852
Free PMC article.
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