Florian P - Search Results

1

Novel inhibitor ZED3197 as potential drug candidate in anticoagulation targeting coagulation FXIIIa (F13a).

Pasternack R, Büchold C, Jähnig R, Pelzer C, Sommer M, Heil A, Florian P, Nowak G, Gerlach U, Hils M. Pasternack R, et al. Among authors: florian p. J Thromb Haemost. 2020 Jan;18(1):191-200. doi: 10.1111/jth.14646. Epub 2019 Oct 23. J Thromb Haemost. 2020. PMID: 31578814 Free PMC article.

2

5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.

Meneyrol J, Follmann M, Lassalle G, Wehner V, Barre G, Rousseaux T, Altenburger JM, Petit F, Bocskei Z, Schreuder H, Alet N, Herault JP, Millet L, Dol F, Florian P, Schaeffer P, Sadoun F, Klieber S, Briot C, Bono F, Herbert JM. Meneyrol J, et al. Among authors: florian p. J Med Chem. 2013 Dec 12;56(23):9441-56. doi: 10.1021/jm4005835. Epub 2013 Dec 3. J Med Chem. 2013. PMID: 24175584

3

Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber.

Florian P, Wonerow P, Harder S, Kuczka K, Dubar M, Graff J. Florian P, et al. Eur J Clin Pharmacol. 2017 Aug;73(8):949-956. doi: 10.1007/s00228-017-2264-9. Epub 2017 May 18. Eur J Clin Pharmacol. 2017. PMID: 28523478 Clinical Trial.

4

Selective non-lipid modulator of LPA5 activity in human platelets.

Kozian DH, Evers A, Florian P, Wonerow P, Joho S, Nazare M. Kozian DH, et al. Among authors: florian p. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5239-43. doi: 10.1016/j.bmcl.2012.06.057. Epub 2012 Jun 27. Bioorg Med Chem Lett. 2012. PMID: 22801643

5

Translational drug discovery and development with the use of tissue-relevant biomarkers: Towards more physiological relevance and better prediction of clinical efficacy.

Florian P, Flechsenhar KR, Bartnik E, Ding-Pfennigdorff D, Herrmann M, Bryce PJ, Nestle FO. Florian P, et al. Exp Dermatol. 2020 Jan;29(1):4-14. doi: 10.1111/exd.13942. Epub 2019 Jun 11. Exp Dermatol. 2020. PMID: 30991456 Review.

6

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.

Zech G, Hessler G, Evers A, Weiss T, Florian P, Just M, Czech J, Czechtizky W, Görlitzer J, Ruf S, Kohlmann M, Nazaré M. Zech G, et al. Among authors: florian p. J Med Chem. 2012 Oct 25;55(20):8615-29. doi: 10.1021/jm300771j. Epub 2012 Oct 4. J Med Chem. 2012. PMID: 22984835

7

In vivo visualization of osteoarthritic hypertrophic lesions.

Hu HY, Lim NH, Juretschke HP, Ding-Pfennigdorff D, Florian P, Kohlmann M, Kandira A, Peter von Kries J, Saas J, Rudolphi KA, Wendt KU, Nagase H, Plettenburg O, Nazare M, Schultz C. Hu HY, et al. Among authors: florian p. Chem Sci. 2015 Nov 1;6(11):6256-6261. doi: 10.1039/c5sc01301a. Epub 2015 Aug 12. Chem Sci. 2015. PMID: 30090244 Free PMC article.

8

LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation.

Pipper C, Bordag N, Reiter B, Economides K, Florian P, Birngruber T, Sinner F, Bodenlenz M, Eberl A. Pipper C, et al. Among authors: florian p. J Lipid Res. 2019 Apr;60(4):758-766. doi: 10.1194/jlr.M087221. Epub 2019 Jan 29. J Lipid Res. 2019. PMID: 30696699 Free PMC article.

9

The specific fates of tight junction proteins in apoptotic epithelial cells.

Bojarski C, Weiske J, Schöneberg T, Schröder W, Mankertz J, Schulzke JD, Florian P, Fromm M, Tauber R, Huber O. Bojarski C, et al. Among authors: florian p. J Cell Sci. 2004 Apr 15;117(Pt 10):2097-107. doi: 10.1242/jcs.01071. Epub 2004 Mar 30. J Cell Sci. 2004. PMID: 15054114

10

Single-cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions.

Florian P, Schöneberg T, Schulzke JD, Fromm M, Gitter AH. Florian P, et al. J Physiol. 2002 Dec 1;545(2):485-99. doi: 10.1113/jphysiol.2002.031161. J Physiol. 2002. PMID: 12456828 Free PMC article.

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