Flaherty DP - Search Results

1

Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1.

Imhoff RD, Patel R, Safdar MH, Jones HBL, Pinto-Fernandez A, Vendrell I, Chen H, Muli CS, Krabill AD, Kessler BM, Wendt MK, Das C, Flaherty DP. Imhoff RD, et al. Among authors: flaherty dp. J Med Chem. 2024 Mar 28;67(6):4496-4524. doi: 10.1021/acs.jmedchem.3c01661. Epub 2024 Mar 15. J Med Chem. 2024. PMID: 38488146

2

Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity.

Matharu DS, Flaherty DP, Simpson DS, Schroeder CE, Chung D, Yan D, Noah JW, Jonsson CB, White EL, Aubé J, Plemper RK, Severson WE, Golden JE. Matharu DS, et al. Among authors: flaherty dp. J Med Chem. 2014 Dec 26;57(24):10314-28. doi: 10.1021/jm500902x. Epub 2014 Dec 4. J Med Chem. 2014. PMID: 25399509 Free PMC article.

3

Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus.

Ha L, Colquhoun J, Noinaj N, Das C, Dunman PM, Flaherty DP. Ha L, et al. Among authors: flaherty dp. Acta Crystallogr F Struct Biol Commun. 2018 Oct 1;74(Pt 10):632-637. doi: 10.1107/S2053230X18011512. Epub 2018 Sep 19. Acta Crystallogr F Struct Biol Commun. 2018. PMID: 30279314 Free PMC article.

4

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca²⁺/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain.

Kaur J, Soto-Velasquez M, Ding Z, Ghanbarpour A, Lill MA, van Rijn RM, Watts VJ, Flaherty DP. Kaur J, et al. Among authors: flaherty dp. Eur J Med Chem. 2019 Jan 15;162:568-585. doi: 10.1016/j.ejmech.2018.11.036. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30472604 Free PMC article.

5

Ubiquitin C-Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor.

Krabill AD, Chen H, Hussain S, Feng C, Abdullah A, Das C, Aryal UK, Post CB, Wendt MK, Galardy PJ, Flaherty DP. Krabill AD, et al. Among authors: flaherty dp. Chembiochem. 2020 Mar 2;21(5):712-722. doi: 10.1002/cbic.201900434. Epub 2019 Nov 7. Chembiochem. 2020. PMID: 31449350 Free PMC article.

6

Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus.

Kaur J, Cao X, Abutaleb NS, Elkashif A, Graboski AL, Krabill AD, AbdelKhalek AH, An W, Bhardwaj A, Seleem MN, Flaherty DP. Kaur J, et al. Among authors: flaherty dp. J Med Chem. 2020 Sep 10;63(17):9540-9562. doi: 10.1021/acs.jmedchem.0c00734. Epub 2020 Aug 11. J Med Chem. 2020. PMID: 32787141 Free PMC article.

7

Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases.

Hewitt CS, Krabill AD, Das C, Flaherty DP. Hewitt CS, et al. Among authors: flaherty dp. Biochemistry. 2020 Sep 22;59(37):3447-3462. doi: 10.1021/acs.biochem.9b01076. Epub 2020 Sep 8. Biochemistry. 2020. PMID: 32865982

8

Corrigendum: Ubiquitin C-Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor.

Krabill AD, Chen H, Hussain S, Feng C, Abdullah A, Hewitt CS, Das C, Aryal UK, Post CB, Wendt MK, Galardy PJ, Flaherty DP. Krabill AD, et al. Among authors: flaherty dp. Chembiochem. 2020 Sep 14;21(18):2701. doi: 10.1002/cbic.202000493. Epub 2020 Aug 25. Chembiochem. 2020. PMID: 32931129 No abstract available.

9

Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA.

Sheedlo MJ, Kenny S, Podkorytov IS, Brown K, Ma J, Iyer S, Hewitt CS, Arbough T, Mikhailovskii O, Flaherty DP, Wilson MA, Skrynnikov NR, Das C. Sheedlo MJ, et al. Among authors: flaherty dp. Biochemistry. 2021 Mar 2;60(8):584-596. doi: 10.1021/acs.biochem.0c00760. Epub 2021 Feb 14. Biochemistry. 2021. PMID: 33583181 Free PMC article.

10

Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.

Krabill AD, Chen H, Hussain S, Hewitt CS, Imhoff RD, Muli CS, Das C, Galardy PJ, Wendt MK, Flaherty DP. Krabill AD, et al. Among authors: flaherty dp. Molecules. 2021 Feb 25;26(5):1227. doi: 10.3390/molecules26051227. Molecules. 2021. PMID: 33668938 Free PMC article.

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