Fisher C - Search Results

1

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids.

Rodrigues D, Coyle L, Füzi B, Ferreira S, Jo H, Herpers B, Chung SW, Fisher C, Kleinjans JCS, Jennen D, de Kok TM. Rodrigues D, et al. Among authors: fisher c. Int J Mol Sci. 2022 Jan 24;23(3):1286. doi: 10.3390/ijms23031286. Int J Mol Sci. 2022. PMID: 35163210 Free PMC article.

2

Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium.

Ferreira S, Fisher C, Furlong LI, Laplanche L, Park BK, Pin C, Saez-Rodriguez J, Trairatphisan P. Ferreira S, et al. Among authors: fisher c. Chem Res Toxicol. 2020 Jan 21;33(1):7-9. doi: 10.1021/acs.chemrestox.9b00499. Epub 2020 Jan 7. Chem Res Toxicol. 2020. PMID: 31909603

3

A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids.

Rodrigues D, Herpers B, Ferreira S, Jo H, Fisher C, Coyle L, Chung SW, Kleinjans JCS, Jennen DGJ, de Kok TM. Rodrigues D, et al. Among authors: fisher c. Int J Mol Sci. 2022 Feb 17;23(4):2213. doi: 10.3390/ijms23042213. Int J Mol Sci. 2022. PMID: 35216325 Free PMC article.

4

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp^® simulator.

Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY. Khalidi H, et al. Among authors: fisher c. Front Pharmacol. 2022 Aug 25;13:929200. doi: 10.3389/fphar.2022.929200. eCollection 2022. Front Pharmacol. 2022. PMID: 36091744 Free PMC article.

5

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability.

Vlasveld M, Callegaro G, Fisher C, Eakins J, Walker P, Lok S, van Oost S, de Jong B, Pellegrino-Coppola D, Burger G, Wink S, van de Water B. Vlasveld M, et al. Among authors: fisher c. Liver Int. 2024 Mar;44(3):760-775. doi: 10.1111/liv.15822. Epub 2024 Jan 13. Liver Int. 2024. PMID: 38217387

6

VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays.

Fisher C, Siméon S, Jamei M, Gardner I, Bois YF. Fisher C, et al. Toxicol In Vitro. 2019 Aug;58:42-50. doi: 10.1016/j.tiv.2018.12.017. Epub 2018 Dec 29. Toxicol In Vitro. 2019. PMID: 30599189 Free article.

7

Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models.

Proença S, Escher BI, Fischer FC, Fisher C, Grégoire S, Hewitt NJ, Nicol B, Paini A, Kramer NI. Proença S, et al. Among authors: fisher c. Toxicol In Vitro. 2021 Jun;73:105133. doi: 10.1016/j.tiv.2021.105133. Epub 2021 Mar 1. Toxicol In Vitro. 2021. PMID: 33662518 Free article. Review.

8

Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action.

Escher SE, Aguayo-Orozco A, Benfenati E, Bitsch A, Braunbeck T, Brotzmann K, Bois F, van der Burg B, Castel J, Exner T, Gadaleta D, Gardner I, Goldmann D, Hatley O, Golbamaki N, Graepel R, Jennings P, Limonciel A, Long A, Maclennan R, Mombelli E, Norinder U, Jain S, Capinha LS, Taboureau OT, Tolosa L, Vrijenhoek NG, van Vugt-Lussenburg BMA, Walker P, van de Water B, Wehr M, White A, Zdrazil B, Fisher C. Escher SE, et al. Among authors: fisher c. Toxicol In Vitro. 2022 Mar;79:105269. doi: 10.1016/j.tiv.2021.105269. Epub 2021 Oct 29. Toxicol In Vitro. 2022. PMID: 34757180 Free article.

9

Modeling Exposure to Understand and Predict Kidney Injury.

Li Z, Fisher C, Gardner I, Ghosh A, Litchfield J, Maurer TS. Li Z, et al. Among authors: fisher c. Semin Nephrol. 2019 Mar;39(2):176-189. doi: 10.1016/j.semnephrol.2018.12.006. Semin Nephrol. 2019. PMID: 30827340 Review.

10

Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs.

Siméon S, Brotzmann K, Fisher C, Gardner I, Silvester S, Maclennan R, Walker P, Braunbeck T, Bois FY. Siméon S, et al. Among authors: fisher c. Reprod Toxicol. 2020 Apr;93:219-229. doi: 10.1016/j.reprotox.2020.02.010. Epub 2020 Feb 28. Reprod Toxicol. 2020. PMID: 32114065

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