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Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
Karam S, Margaria JP, Bourcier A, Mika D, Varin A, Bedioune I, Lindner M, Bouadjel K, Dessillons M, Gaudin F, Lefebvre F, Mateo P, Lechène P, Gomez S, Domergue V, Robert P, Coquard C, Algalarrondo V, Samuel JL, Michel JB, Charpentier F, Ghigo A, Hirsch E, Fischmeister R, Leroy J, Vandecasteele G. Karam S, et al. Among authors: fischmeister r. Circulation. 2020 Jul 14;142(2):161-174. doi: 10.1161/CIRCULATIONAHA.119.042573. Epub 2020 Apr 8. Circulation. 2020. PMID: 32264695
cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes.
Rivet-Bastide M, Vandecasteele G, Hatem S, Verde I, Bénardeau A, Mercadier JJ, Fischmeister R. Rivet-Bastide M, et al. Among authors: fischmeister r. J Clin Invest. 1997 Jun 1;99(11):2710-8. doi: 10.1172/JCI119460. J Clin Invest. 1997. PMID: 9169501 Free PMC article.
Recently, EHNA was shown to block the activity of purified soluble cGMPstimulated phosphodiesterase (PDE2) from frog, human, and porcine heart with an apparent Ki value of approximately 1 microM and with negligible effects on Ca2+/calmodulin PDE (PDE1), cGMP-inhibited PDE (PDE3), …
Recently, EHNA was shown to block the activity of purified soluble cGMPstimulated phosphodiesterase (PDE2) from frog, human, and porcine hea …
178 results