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Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection.
Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Yao C, et al. Among authors: fioravanti j. Nat Immunol. 2019 Jul;20(7):890-901. doi: 10.1038/s41590-019-0403-4. Epub 2019 Jun 17. Nat Immunol. 2019. PMID: 31209400 Free PMC article.
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity.
Gautam S, Fioravanti J, Zhu W, Le Gall JB, Brohawn P, Lacey NE, Hu J, Hocker JD, Hawk NV, Kapoor V, Telford WG, Gurusamy D, Yu Z, Bhandoola A, Xue HH, Roychoudhuri R, Higgs BW, Restifo NP, Bender TP, Ji Y, Gattinoni L. Gautam S, et al. Among authors: fioravanti j. Nat Immunol. 2019 Mar;20(3):337-349. doi: 10.1038/s41590-018-0311-z. Epub 2019 Feb 18. Nat Immunol. 2019. PMID: 30778251 Free PMC article.
miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate.
Ji Y, Fioravanti J, Zhu W, Wang H, Wu T, Hu J, Lacey NE, Gautam S, Le Gall JB, Yang X, Hocker JD, Escobar TM, He S, Dell'Orso S, Hawk NV, Kapoor V, Telford WG, Di Croce L, Muljo SA, Zhang Y, Sartorelli V, Gattinoni L. Ji Y, et al. Among authors: fioravanti j. Nat Commun. 2019 May 14;10(1):2157. doi: 10.1038/s41467-019-09882-8. Nat Commun. 2019. PMID: 31089138 Free PMC article.
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity.
Hermans D, Gautam S, García-Cañaveras JC, Gromer D, Mitra S, Spolski R, Li P, Christensen S, Nguyen R, Lin JX, Oh J, Du N, Veenbergen S, Fioravanti J, Ebina-Shibuya R, Bleck C, Neckers LM, Rabinowitz JD, Gattinoni L, Leonard WJ. Hermans D, et al. Among authors: fioravanti j. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6047-6055. doi: 10.1073/pnas.1920413117. Epub 2020 Mar 2. Proc Natl Acad Sci U S A. 2020. PMID: 32123114 Free PMC article.
T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy.
Yamamoto TN, Lee PH, Vodnala SK, Gurusamy D, Kishton RJ, Yu Z, Eidizadeh A, Eil R, Fioravanti J, Gattinoni L, Kochenderfer JN, Fry TJ, Aksoy BA, Hammerbacher JE, Cruz AC, Siegel RM, Restifo NP, Klebanoff CA. Yamamoto TN, et al. Among authors: fioravanti j. J Clin Invest. 2019 Feb 25;129(4):1551-1565. doi: 10.1172/JCI121491. eCollection 2019 Feb 25. J Clin Invest. 2019. PMID: 30694219 Free PMC article.
Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology.
Fioravanti J, Di Lucia P, Magini D, Moalli F, Boni C, Benechet AP, Fumagalli V, Inverso D, Vecchi A, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M. Fioravanti J, et al. J Hepatol. 2017 Sep;67(3):543-548. doi: 10.1016/j.jhep.2017.04.020. Epub 2017 May 5. J Hepatol. 2017. PMID: 28483675 Free PMC article.
Inflammatory monocytes hinder antiviral B cell responses.
Sammicheli S, Kuka M, Di Lucia P, de Oya NJ, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, de la Torre JC, Guidotti LG, Iannacone M. Sammicheli S, et al. Among authors: fioravanti j. Sci Immunol. 2016 Oct 21;1(4):eaah6789. doi: 10.1126/sciimmunol.aah6789. Sci Immunol. 2016. PMID: 27868108 Free PMC article.
Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens.
Jiménez de Oya N, De Giovanni M, Fioravanti J, Übelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M. Jiménez de Oya N, et al. Among authors: fioravanti j. EMBO Mol Med. 2017 Nov;9(11):1482-1490. doi: 10.15252/emmm.201707732. EMBO Mol Med. 2017. PMID: 28899929 Free PMC article.
Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein A-I.
Berraondo P, Di Scala M, Korolowicz K, Thampi LM, Otano I, Suarez L, Fioravanti J, Aranda F, Ardaiz N, Yang J, Kallakury BV, Tucker RD, Vasquez M, Menne S, Prieto J, González-Aseguinolaza G. Berraondo P, et al. Among authors: fioravanti j. J Hepatol. 2015 Aug;63(2):329-36. doi: 10.1016/j.jhep.2015.02.048. Epub 2015 Mar 12. J Hepatol. 2015. PMID: 25772035 Free PMC article.
36 results