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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH, Hong WD, Pidathala C, Riley C, Murphy B, Aljayyoussi G, Gamo FJ, Sanz L, Rodrigues J, Cortes CG, Herreros E, Angulo-Barturén I, Jiménez-Díaz MB, Bazaga SF, Martínez-Martínez MS, Campo B, Sharma R, Ryan E, Shackleford DM, Campbell S, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Palmer MJ, Copple IM, Mercer AE, Ruecker A, Delves MJ, Sinden RE, Siegl P, Davies J, Rochford R, Kocken CHM, Zeeman AM, Nixon GL, Biagini GA, Ward SA. O'Neill PM, et al. Among authors: fidock da. Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159. Nat Commun. 2017. PMID: 28537265 Free PMC article.
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Bray PG, Mungthin M, Hastings IM, Biagini GA, Saidu DK, Lakshmanan V, Johnson DJ, Hughes RH, Stocks PA, O'Neill PM, Fidock DA, Warhurst DC, Ward SA. Bray PG, et al. Among authors: fidock da. Mol Microbiol. 2006 Oct;62(1):238-51. doi: 10.1111/j.1365-2958.2006.05368.x. Epub 2006 Aug 31. Mol Microbiol. 2006. PMID: 16956382 Free PMC article.
Transporters involved in resistance to antimalarial drugs.
Valderramos SG, Fidock DA. Valderramos SG, et al. Among authors: fidock da. Trends Pharmacol Sci. 2006 Nov;27(11):594-601. doi: 10.1016/j.tips.2006.09.005. Epub 2006 Sep 25. Trends Pharmacol Sci. 2006. PMID: 16996622 Free PMC article. Review.
288 results