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Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.
Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G. Lessard F, et al. Among authors: ferbeyre g. Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941930
Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.
Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I. Hulea L, et al. Among authors: ferbeyre g. Cell Metab. 2018 Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001. Epub 2018 Sep 20. Cell Metab. 2018. PMID: 30244971 Free PMC article.
Circumventing senescence is associated with stem cell properties and metformin sensitivity.
Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G. Deschênes-Simard X, et al. Among authors: ferbeyre g. Aging Cell. 2019 Apr;18(2):e12889. doi: 10.1111/acel.12889. Epub 2019 Jan 6. Aging Cell. 2019. PMID: 30614183 Free PMC article.
The senescence-associated secretory phenotype and its regulation.
Lopes-Paciencia S, Saint-Germain E, Rowell MC, Ruiz AF, Kalegari P, Ferbeyre G. Lopes-Paciencia S, et al. Among authors: ferbeyre g. Cytokine. 2019 May;117:15-22. doi: 10.1016/j.cyto.2019.01.013. Epub 2019 Feb 16. Cytokine. 2019. PMID: 30776684 Review.
Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex.
Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F. Del Toro N, et al. Among authors: ferbeyre g. Cell Cycle. 2019 Mar-Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. Epub 2019 Mar 28. Cell Cycle. 2019. PMID: 30874462 Free PMC article.
Phosphorylation of SOCS1 Inhibits the SOCS1-p53 Tumor Suppressor Axis.
Saint-Germain E, Mignacca L, Huot G, Acevedo M, Moineau-Vallée K, Calabrese V, Bourdeau V, Rowell MC, Ilangumaran S, Lessard F, Ferbeyre G. Saint-Germain E, et al. Among authors: ferbeyre g. Cancer Res. 2019 Jul 1;79(13):3306-3319. doi: 10.1158/0008-5472.CAN-18-1503. Epub 2019 May 17. Cancer Res. 2019. PMID: 31101761
Metformin turns off the metabolic switch of pancreatic cancer.
Deschênes-Simard X, Rowell MC, Ferbeyre G. Deschênes-Simard X, et al. Among authors: ferbeyre g. Aging (Albany NY). 2019 Dec 12;11(23):10793-10795. doi: 10.18632/aging.102622. Epub 2019 Dec 12. Aging (Albany NY). 2019. PMID: 31831715 Free PMC article. No abstract available.
125 results