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STAT3 and STAT5 Activation in Solid Cancers.
Igelmann S, Neubauer HA, Ferbeyre G. Igelmann S, et al. Among authors: ferbeyre g. Cancers (Basel). 2019 Sep 25;11(10):1428. doi: 10.3390/cancers11101428. Cancers (Basel). 2019. PMID: 31557897 Free PMC article. Review.
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.
Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G. Deschênes-Simard X, et al. Among authors: ferbeyre g. Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18. Genes Dev. 2013. PMID: 23599344 Free PMC article.
Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.
Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G. Lessard F, et al. Among authors: ferbeyre g. Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941930
Circumventing senescence is associated with stem cell properties and metformin sensitivity.
Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G. Deschênes-Simard X, et al. Among authors: ferbeyre g. Aging Cell. 2019 Apr;18(2):e12889. doi: 10.1111/acel.12889. Epub 2019 Jan 6. Aging Cell. 2019. PMID: 30614183 Free PMC article.
Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex.
Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F. Del Toro N, et al. Among authors: ferbeyre g. Cell Cycle. 2019 Mar-Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. Epub 2019 Mar 28. Cell Cycle. 2019. PMID: 30874462 Free PMC article.
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Igelmann S, Lessard F, Uchenunu O, Bouchard J, Fernandez-Ruiz A, Rowell MC, Lopes-Paciencia S, Papadopoli D, Fouillen A, Ponce KJ, Huot G, Mignacca L, Benfdil M, Kalegari P, Wahba HM, Pencik J, Vuong N, Quenneville J, Guillon J, Bourdeau V, Hulea L, Gagnon E, Kenner L, Moriggl R, Nanci A, Pollak MN, Omichinski JG, Topisirovic I, Ferbeyre G. Igelmann S, et al. Among authors: ferbeyre g. Mol Cell. 2021 Sep 16;81(18):3848-3865.e19. doi: 10.1016/j.molcel.2021.08.028. Mol Cell. 2021. PMID: 34547241 Free article.
Cellular senescence limits translational readthrough.
Del Toro N, Lessard F, Bouchard J, Mobasheri N, Guillon J, Igelmann S, Tardif S, Buffard T, Bourdeau V, Brakier-Gingras L, Ferbeyre G. Del Toro N, et al. Among authors: ferbeyre g. Biol Open. 2021 Dec 1;10(12):bio058688. doi: 10.1242/bio.058688. Epub 2021 Dec 2. Biol Open. 2021. PMID: 34676390 Free PMC article.
125 results