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Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms.
Uriarte M, De Francesco PN, Fernández G, Castrogiovanni D, D'Arcangelo M, Imbernon M, Cantel S, Denoyelle S, Fehrentz JA, Praetorius J, Prevot V, Perello M. Uriarte M, et al. Among authors: fehrentz ja. Mol Cell Endocrinol. 2021 Dec 1;538:111449. doi: 10.1016/j.mce.2021.111449. Epub 2021 Aug 31. Mol Cell Endocrinol. 2021. PMID: 34478806
Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region.
Barrile F, M'Kadmi C, De Francesco PN, Cabral A, García Romero G, Mustafá ER, Cantel S, Damian M, Mary S, Denoyelle S, Banères JL, Marie J, Raingo J, Fehrentz JA, Perelló M. Barrile F, et al. Among authors: fehrentz ja. Mol Cell Endocrinol. 2019 Dec 1;498:110573. doi: 10.1016/j.mce.2019.110573. Epub 2019 Sep 6. Mol Cell Endocrinol. 2019. PMID: 31499133
Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice.
Aguggia JP, Cornejo MP, Fernandez G, De Francesco PN, Mani BK, Cassano D, Cabral A, Valdivia S, García Romero G, Reynaldo M, Fehrentz JA, Zigman JM, Perello M. Aguggia JP, et al. Among authors: fehrentz ja. Psychoneuroendocrinology. 2022 May;139:105716. doi: 10.1016/j.psyneuen.2022.105716. Epub 2022 Mar 9. Psychoneuroendocrinology. 2022. PMID: 35290931
GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.
Fernandez G, Cabral A, De Francesco PN, Uriarte M, Reynaldo M, Castrogiovanni D, Zubiría G, Giovambattista A, Cantel S, Denoyelle S, Fehrentz JA, Tolle V, Schiöth HB, Perello M. Fernandez G, et al. Among authors: fehrentz ja. Cell Mol Life Sci. 2022 May 4;79(5):277. doi: 10.1007/s00018-022-04302-5. Cell Mol Life Sci. 2022. PMID: 35504998
Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin.
Péraldi-Roux S, Bayle M, M'Kadmi C, Damian M, Vaillé J, Fernandez G, Cornejo MP, Marie J, Banères JL, Ben Haj Salah K, Fehrentz JA, Cantel S, Perello M, Denoyelle S, Oiry C, Neasta J. Péraldi-Roux S, et al. Among authors: fehrentz ja. Biochem Pharmacol. 2022 Aug;202:115114. doi: 10.1016/j.bcp.2022.115114. Epub 2022 May 31. Biochem Pharmacol. 2022. PMID: 35659880
N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor.
M'Kadmi C, Cabral A, Barrile F, Giribaldi J, Cantel S, Damian M, Mary S, Denoyelle S, Dutertre S, Péraldi-Roux S, Neasta J, Oiry C, Banères JL, Marie J, Perello M, Fehrentz JA. M'Kadmi C, et al. Among authors: fehrentz ja. J Med Chem. 2019 Jan 24;62(2):965-973. doi: 10.1021/acs.jmedchem.8b01644. Epub 2018 Dec 24. J Med Chem. 2019. PMID: 30543423
136 results