Fehr AR - Search Results

1

An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors.

O'Connor JJ, Ferraris D, Fehr AR. O'Connor JJ, et al. Among authors: fehr ar. Pathogens. 2023 Oct 7;12(10):1221. doi: 10.3390/pathogens12101221. Pathogens. 2023. PMID: 37887737 Free PMC article. Review.

2

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.

Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR. Grunewald ME, et al. Among authors: fehr ar. PLoS Pathog. 2019 May 16;15(5):e1007756. doi: 10.1371/journal.ppat.1007756. eCollection 2019 May. PLoS Pathog. 2019. PMID: 31095648 Free PMC article.

3

An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication.

Voth LS, O'Connor JJ, Kerr CM, Doerger E, Schwarting N, Sperstad P, Johnson DK, Fehr AR. Voth LS, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2021 Mar 31:2021.03.30.437796. doi: 10.1101/2021.03.30.437796. bioRxiv. 2021. PMID: 33821264 Free PMC article. Updated. Preprint.

4

Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication.

Voth LS, O'Connor JJ, Kerr CM, Doerger E, Schwarting N, Sperstad P, Johnson DK, Fehr AR. Voth LS, et al. Among authors: fehr ar. J Virol. 2021 Jul 12;95(15):e0076621. doi: 10.1128/JVI.00766-21. Epub 2021 Jul 12. J Virol. 2021. PMID: 34011547 Free PMC article.

5

High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain.

Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, Wei H, Leung AKL. Dasovich M, et al. Among authors: fehr ar. ACS Chem Biol. 2022 Jan 21;17(1):17-23. doi: 10.1021/acschembio.1c00721. Epub 2021 Dec 14. ACS Chem Biol. 2022. PMID: 34904435

6

The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses.

Leung AKL, Griffin DE, Bosch J, Fehr AR. Leung AKL, et al. Among authors: fehr ar. Pathogens. 2022 Jan 14;11(1):94. doi: 10.3390/pathogens11010094. Pathogens. 2022. PMID: 35056042 Free PMC article.

7

Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening.

Roy A, Alhammad YM, McDonald P, Johnson DK, Zhuo J, Wazir S, Ferraris D, Lehtiö L, Leung AKL, Fehr AR. Roy A, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2022 Mar 2:2022.03.01.482536. doi: 10.1101/2022.03.01.482536. bioRxiv. 2022. PMID: 35262075 Free PMC article. Updated. Preprint.

8

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain.

Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Sherrill LM, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2022 Feb 28:2022.02.27.482176. doi: 10.1101/2022.02.27.482176. bioRxiv. 2022. PMID: 35262078 Free PMC article. Updated. Preprint.

9

Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain.

Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Sherrill LM, et al. Among authors: fehr ar. Bioorg Med Chem. 2022 Aug 1;67:116788. doi: 10.1016/j.bmc.2022.116788. Epub 2022 May 11. Bioorg Med Chem. 2022. PMID: 35597097 Free PMC article.

10

Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening.

Roy A, Alhammad YM, McDonald P, Johnson DK, Zhuo J, Wazir S, Ferraris D, Lehtiö L, Leung AKL, Fehr AR. Roy A, et al. Among authors: fehr ar. Antiviral Res. 2022 Jul;203:105344. doi: 10.1016/j.antiviral.2022.105344. Epub 2022 May 19. Antiviral Res. 2022. PMID: 35598780 Free PMC article.

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