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Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia.
Sainte Marie Y, Toulon A, Paus R, Maubec E, Cherfa A, Grossin M, Descamps V, Clemessy M, Gasc JM, Peuchmaur M, Glick A, Farman N, Jaisser F. Sainte Marie Y, et al. Among authors: farman n. Am J Pathol. 2007 Sep;171(3):846-60. doi: 10.2353/ajpath.2007.060991. Epub 2007 Aug 3. Am J Pathol. 2007. PMID: 17675581 Free PMC article.
Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy.
Zhao M, Célérier I, Bousquet E, Jeanny JC, Jonet L, Savoldelli M, Offret O, Curan A, Farman N, Jaisser F, Behar-Cohen F. Zhao M, et al. Among authors: farman n. J Clin Invest. 2012 Jul;122(7):2672-9. doi: 10.1172/JCI61427. Epub 2012 Jun 11. J Clin Invest. 2012. PMID: 22684104 Free PMC article.
Aldosterone-specific activation of cardiomyocyte mineralocorticoid receptor in vivo.
Messaoudi S, Gravez B, Tarjus A, Pelloux V, Ouvrard-Pascaud A, Delcayre C, Samuel J, Launay JM, Sierra-Ramos C, Alvarez de la Rosa D, Clément K, Farman N, Jaisser F. Messaoudi S, et al. Among authors: farman n. Hypertension. 2013 Feb;61(2):361-7. doi: 10.1161/HYPERTENSIONAHA.112.198986. Epub 2013 Jan 7. Hypertension. 2013. PMID: 23297371
Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin.
Maubec E, Laouénan C, Deschamps L, Nguyen VT, Scheer-Senyarich I, Wackenheim-Jacobs AC, Steff M, Duhamel S, Tubiana S, Brahimi N, Leclerc-Mercier S, Crickx B, Perret C, Aractingi S, Escoubet B, Duval X, Arnaud P, Jaisser F, Mentré F, Farman N. Maubec E, et al. Among authors: farman n. J Invest Dermatol. 2015 Jul;135(7):1781-1789. doi: 10.1038/jid.2015.44. Epub 2015 Feb 10. J Invest Dermatol. 2015. PMID: 25668238 Free article. Clinical Trial.
154 results