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STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C. Heichler C, et al. Among authors: farin hf. Gut. 2020 Jul;69(7):1269-1282. doi: 10.1136/gutjnl-2019-319200. Epub 2019 Nov 4. Gut. 2020. PMID: 31685519
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer.
Varga J, Nicolas A, Petrocelli V, Pesic M, Mahmoud A, Michels BE, Etlioglu E, Yepes D, Häupl B, Ziegler PK, Bankov K, Wild PJ, Wanninger S, Medyouf H, Farin HF, Tejpar S, Oellerich T, Ruland J, Siebel CW, Greten FR. Varga J, et al. Among authors: farin hf. J Exp Med. 2020 Oct 5;217(10):e20191515. doi: 10.1084/jem.20191515. J Exp Med. 2020. PMID: 32749453 Free PMC article.
Colorectal Cancer Organoid-Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses.
Farin HF, Mosa MH, Ndreshkjana B, Grebbin BM, Ritter B, Menche C, Kennel KB, Ziegler PK, Szabó L, Bollrath J, Rieder D, Michels BE, Kress A, Bozlar M, Darvishi T, Stier S, Kur IM, Bankov K, Kesselring R, Fichtner-Feigl S, Brüne B, Goetze TO, Al-Batran SE, Brandts CH, Bechstein WO, Wild PJ, Weigert A, Müller S, Knapp S, Trajanoski Z, Greten FR. Farin HF, et al. Cancer Discov. 2023 Oct 5;13(10):2192-2211. doi: 10.1158/2159-8290.CD-23-0050. Cancer Discov. 2023. PMID: 37489084 Free PMC article.
Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.
Weren RD, Venkatachalam R, Cazier JB, Farin HF, Kets CM, de Voer RM, Vreede L, Verwiel ET, van Asseldonk M, Kamping EJ, Kiemeney LA, Neveling K, Aben KK, Carvajal-Carmona L, Nagtegaal ID, Schackert HK, Clevers H, van de Wetering M, Tomlinson IP, Ligtenberg MJ, Hoogerbrugge N, Geurts van Kessel A, Kuiper RP. Weren RD, et al. Among authors: farin hf. J Pathol. 2015 Jun;236(2):155-64. doi: 10.1002/path.4520. Epub 2015 Mar 26. J Pathol. 2015. PMID: 25712196 Free PMC article.
YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.
Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. Taniguchi K, et al. Among authors: farin hf. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27. Proc Natl Acad Sci U S A. 2017. PMID: 28130546 Free PMC article.
Human colon organoids reveal distinct physiologic and oncogenic Wnt responses.
Michels BE, Mosa MH, Grebbin BM, Yepes D, Darvishi T, Hausmann J, Urlaub H, Zeuzem S, Kvasnicka HM, Oellerich T, Farin HF. Michels BE, et al. Among authors: farin hf. J Exp Med. 2019 Mar 4;216(3):704-720. doi: 10.1084/jem.20180823. Epub 2019 Feb 21. J Exp Med. 2019. PMID: 30792186 Free PMC article.
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH. Schwiebs A, et al. Among authors: farin hf. Oncogene. 2019 Jun;38(24):4788-4803. doi: 10.1038/s41388-019-0758-x. Epub 2019 Feb 28. Oncogene. 2019. PMID: 30816345
52 results