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The guidance receptor plexin D1 is a mechanosensor in endothelial cells.
Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E. Mehta V, et al. Among authors: fang y. Nature. 2020 Feb;578(7794):290-295. doi: 10.1038/s41586-020-1979-4. Epub 2020 Feb 5. Nature. 2020. PMID: 32025034 Free PMC article.
NOTCH1 is a mechanosensor in adult arteries.
Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. Mack JJ, et al. Among authors: fang y. Nat Commun. 2017 Nov 20;8(1):1620. doi: 10.1038/s41467-017-01741-8. Nat Commun. 2017. PMID: 29158473 Free PMC article.
Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y. Krause MD, et al. Among authors: fang y. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11349-E11358. doi: 10.1073/pnas.1810568115. Epub 2018 Nov 14. Proc Natl Acad Sci U S A. 2018. PMID: 30429326 Free PMC article.
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling AI, Guzy RD, Fang Y, Yang KC. Lee TH, et al. Among authors: fang y. Nat Commun. 2020 Aug 26;11(1):4254. doi: 10.1038/s41467-020-18047-x. Nat Commun. 2020. PMID: 32848143 Free PMC article.
JAG1-NOTCH4 mechanosensing drives atherosclerosis.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis SE, Chico TJ, Serbanovic-Canic J, Evans PC. Souilhol C, et al. Among authors: fang y. Sci Adv. 2022 Sep 2;8(35):eabo7958. doi: 10.1126/sciadv.abo7958. Epub 2022 Aug 31. Sci Adv. 2022. PMID: 36044575 Free PMC article.
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