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Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.
Nachmani D, Bothmer AH, Grisendi S, Mele A, Bothmer D, Lee JD, Monteleone E, Cheng K, Zhang Y, Bester AC, Guzzetti A, Mitchell CA, Mendez LM, Pozdnyakova O, Sportoletti P, Martelli MP, Vulliamy TJ, Safra M, Schwartz S, Luzzatto L, Bluteau O, Soulier J, Darnell RB, Falini B, Dokal I, Ito K, Clohessy JG, Pandolfi PP. Nachmani D, et al. Among authors: falini b. Nat Genet. 2019 Oct;51(10):1518-1529. doi: 10.1038/s41588-019-0502-z. Epub 2019 Sep 30. Nat Genet. 2019. PMID: 31570891 Free PMC article.
Nucleophosmin and cancer.
Grisendi S, Mecucci C, Falini B, Pandolfi PP. Grisendi S, et al. Among authors: falini b. Nat Rev Cancer. 2006 Jul;6(7):493-505. doi: 10.1038/nrc1885. Nat Rev Cancer. 2006. PMID: 16794633 Review.
The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.
Sportoletti P, Varasano E, Rossi R, Bereshchenko O, Cecchini D, Gionfriddo I, Bolli N, Tiacci E, Intermesoli T, Zanghì P, Masciulli A, Martelli MP, Falzetti F, Martelli MF, Falini B. Sportoletti P, et al. Among authors: falini b. Blood. 2013 Apr 25;121(17):3447-58. doi: 10.1182/blood-2012-08-449553. Epub 2013 Feb 22. Blood. 2013. PMID: 23435463 Free article.
Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.
Martelli MP, Gionfriddo I, Mezzasoma F, Milano F, Pierangeli S, Mulas F, Pacini R, Tabarrini A, Pettirossi V, Rossi R, Vetro C, Brunetti L, Sportoletti P, Tiacci E, Di Raimondo F, Falini B. Martelli MP, et al. Among authors: falini b. Blood. 2015 May 28;125(22):3455-65. doi: 10.1182/blood-2014-11-611459. Epub 2015 Mar 20. Blood. 2015. PMID: 25795919 Free article.
Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling.
Tripodo C, Burocchi A, Piccaluga PP, Chiodoni C, Portararo P, Cappetti B, Botti L, Gulino A, Isidori A, Liso A, Visani G, Martelli MP, Falini B, Pandolfi PP, Colombo MP, Sangaletti S. Tripodo C, et al. Among authors: falini b. Cancer Res. 2017 Jul 1;77(13):3685-3699. doi: 10.1158/0008-5472.CAN-17-1098. Epub 2017 May 23. Cancer Res. 2017. PMID: 28536276 Free article.
A scale of "bad" co-mutations in NPM1-driven AML.
Falini B, Sportoletti P. Falini B, et al. Blood. 2017 Oct 26;130(17):1877-1879. doi: 10.1182/blood-2017-09-804062. Blood. 2017. PMID: 29074594 Free article. No abstract available.
464 results