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Page 1
Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
Boutard N, Białas A, Sabiniarz A, Guzik P, Banaszak K, Biela A, Bień M, Buda A, Bugaj B, Cieluch E, Cierpich A, Dudek Ł, Eggenweiler HM, Fogt J, Gaik M, Gondela A, Jakubiec K, Jurzak M, Kitlińska A, Kowalczyk P, Kujawa M, Kwiecińska K, Leś M, Lindemann R, Maciuszek M, Mikulski M, Niedziejko P, Obara A, Pawlik H, Rzymski T, Sieprawska-Lupa M, Sowińska M, Szeremeta-Spisak J, Stachowicz A, Tomczyk MM, Wiklik K, Włoszczak Ł, Ziemiańska S, Zarębski A, Brzózka K, Nowak M, Fabritius CH. Boutard N, et al. Among authors: fabritius ch. ChemMedChem. 2019 Jan 8;14(1):169-181. doi: 10.1002/cmdc.201800569. Epub 2018 Dec 6. ChemMedChem. 2019. PMID: 30378281
1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists.
Fabritius CH, Pesonen U, Messinger J, Horvath R, Salo H, Gałęzowski M, Galek M, Stefańska K, Szeremeta-Spisak J, Olszak-Płachta M, Buda A, Adamczyk J, Król M, Prusis P, Sieprawska-Lupa M, Mikulski M, Kuokkanen K, Chapman H, Obuchowicz R, Korjamo T, Jalava N, Nowak M. Fabritius CH, et al. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2610-5. doi: 10.1016/j.bmcl.2016.04.024. Epub 2016 Apr 23. Bioorg Med Chem Lett. 2016. PMID: 27117428
Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Boutard N, Białas A, Sabiniarz A, Guzik P, Banaszak K, Biela A, Bień M, Buda A, Bugaj B, Cieluch E, Cierpich A, Dudek Ł, Eggenweiler HM, Fogt J, Gaik M, Gondela A, Jakubiec K, Jurzak M, Kitlińska A, Kowalczyk P, Kujawa M, Kwiecińska K, Leś M, Lindemann R, Maciuszek M, Mikulski M, Niedziejko P, Obara A, Pawlik H, Rzymski T, Sieprawska-Lupa M, Sowińska M, Szeremeta-Spisak J, Stachowicz A, Tomczyk MM, Wiklik K, Włoszczak Ł, Ziemiańska S, Zarębski A, Brzózka K, Nowak M, Fabritius CH. Boutard N, et al. Among authors: fabritius ch. Bioorg Med Chem Lett. 2019 Feb 15;29(4):646-653. doi: 10.1016/j.bmcl.2018.12.034. Epub 2018 Dec 16. Bioorg Med Chem Lett. 2019. PMID: 30626557
5-Keto-3-cyano-2,4-diaminothiophenes as selective maternal embryonic leucine zipper kinase inhibitors.
Boutard N, Sabiniarz A, Czerwińska K, Jarosz M, Cierpich A, Kolasińska E, Wiklik K, Gluza K, Commandeur C, Buda A, Stasiowska A, Bobowska A, Galek M, Fabritius CH, Bugaj M, Palacz E, Mazan A, Zarębski A, Krawczyńska K, Żurawska M, Zawadzki P, Milik M, Węgrzyn P, Dobrzańska M, Brzózka K, Kowalczyk P. Boutard N, et al. Among authors: fabritius ch. Bioorg Med Chem Lett. 2019 Feb 15;29(4):607-613. doi: 10.1016/j.bmcl.2018.12.051. Epub 2018 Dec 24. Bioorg Med Chem Lett. 2019. PMID: 30626559
Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock.
Dreas A, Kucwaj-Brysz K, Pyziak K, Kulesza U, Wincza E, Fabritius CH, Michalik K, Gabor-Worwa E, Gołas A, Milik M, Masiejczyk M, Majewska E, Pyśniak K, Wójcik-Trechcińska U, Sandowska-Markiewicz Z, Brzózka K, Ostrowski J, Rzymski T, Mikula M. Dreas A, et al. Among authors: fabritius ch. Eur J Med Chem. 2021 Mar 5;213:113057. doi: 10.1016/j.ejmech.2020.113057. Epub 2020 Dec 1. Eur J Med Chem. 2021. PMID: 33303237
5-HT6 receptor antagonists. Design, synthesis, and structure-activity relationship of substituted 2-(1-methyl-4-piperazinyl)pyridines.
Gałęzowski M, Fabritius CH, Pesonen U, Salo H, Olszak-Płachta M, Czerwińska K, Adamczyk J, Król M, Prusis P, Sieprawska-Lupa M, Mikulski M, Kuokkanen K, Obuchowicz R, Korjamo T, Jalava N, Nikiforuk A, Nowak M. Gałęzowski M, et al. Among authors: fabritius ch. Bioorg Med Chem Lett. 2023 Nov 15;96:129497. doi: 10.1016/j.bmcl.2023.129497. Epub 2023 Oct 6. Bioorg Med Chem Lett. 2023. PMID: 37806499
Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors.
Harrison D, Boutard N, Brzozka K, Bugaj M, Chmielewski S, Cierpich A, Doedens JR, Fabritius CRY, Gabel CA, Galezowski M, Kowalczyk P, Levenets O, Mroczkowska M, Palica K, Porter RA, Schultz D, Sowinska M, Topolnicki G, Urbanski P, Woyciechowski J, Watt AP. Harrison D, et al. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127560. doi: 10.1016/j.bmcl.2020.127560. Epub 2020 Sep 18. Bioorg Med Chem Lett. 2020. PMID: 32956781
A new approach to the 8b-azaacenaphthylene ring system.
Kamath A, Fabritius CH, Philouze C, Delair P. Kamath A, et al. Among authors: fabritius ch. Org Biomol Chem. 2015 Oct 14;13(38):9834-43. doi: 10.1039/c5ob01013f. Org Biomol Chem. 2015. PMID: 26280309
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