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Page 1
Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload.
Bartoli F, Bailey MA, Rode B, Mateo P, Antigny F, Bedouet K, Gerbaud P, Gosain R, Plante J, Norman K, Gomez S, Lefebvre F, Rucker-Martin C, Ainscough JFX, Kearney MT, Bruns AF, Shi J, Appleby HL, Young RS, Shawer HM, Debant M, Gomez AM, Beech DJ, Foster R, Benitah JP, Sabourin J. Bartoli F, et al. Circulation. 2020 Jan 21;141(3):199-216. doi: 10.1161/CIRCULATIONAHA.118.038891. Epub 2020 Jan 7. Circulation. 2020. PMID: 31906693 Free PMC article.
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ. Rubaiy HN, et al. J Biol Chem. 2017 May 19;292(20):8158-8173. doi: 10.1074/jbc.M116.773556. Epub 2017 Mar 21. J Biol Chem. 2017. PMID: 28325835 Free PMC article.
Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.
Webster PJ, Littlejohns AT, Gaunt HJ, Young RS, Rode B, Ritchie JE, Stead LF, Harrison S, Droop A, Martin HL, Tomlinson DC, Hyman AJ, Appleby HL, Boxall S, Bruns AF, Li J, Prasad RK, Lodge JPA, Burke DA, Beech DJ. Webster PJ, et al. Oncotarget. 2017 Jun 27;8(26):42288-42299. doi: 10.18632/oncotarget.15039. Oncotarget. 2017. PMID: 28178688 Free PMC article.
Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.
Li J, Bruns AF, Hou B, Rode B, Webster PJ, Bailey MA, Appleby HL, Moss NK, Ritchie JE, Yuldasheva NY, Tumova S, Quinney M, McKeown L, Taylor H, Prasad KR, Burke D, O'Regan D, Porter KE, Foster R, Kearney MT, Beech DJ. Li J, et al. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1987-94. doi: 10.1161/ATVBAHA.115.305969. Epub 2015 Jul 9. Arterioscler Thromb Vasc Biol. 2015. PMID: 26160956 Free PMC article.