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ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer.
Moreno T, Monterde B, González-Silva L, Betancor-Fernández I, Revilla C, Agraz-Doblas A, Freire J, Isidro P, Quevedo L, Blanco R, Montes-Moreno S, Cereceda L, Astudillo A, Casar B, Crespo P, Morales Torres C, Scaffidi P, Gómez-Román J, Salido E, Varela I. Moreno T, et al. Oncogene. 2021 Apr;40(16):2923-2935. doi: 10.1038/s41388-021-01748-y. Epub 2021 Mar 19. Oncogene. 2021. PMID: 33742126 Free PMC article.
Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis.
Morales Torres C, Wu MY, Hobor S, Wainwright EN, Martin MJ, Patel H, Grey W, Grönroos E, Howell S, Carvalho J, Snijders AP, Bustin M, Bonnet D, Smith PD, Swanton C, Howell M, Scaffidi P. Morales Torres C, et al. Nat Commun. 2020 Apr 14;11(1):1792. doi: 10.1038/s41467-020-15615-z. Nat Commun. 2020. PMID: 32286289 Free PMC article.
The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.
Torres CM, Biran A, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben-Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E, Scaffidi P. Torres CM, et al. Science. 2016 Sep 30;353(6307):aaf1644. doi: 10.1126/science.aaf1644. Science. 2016. PMID: 27708074 Free PMC article.