FC001060/WT_/Wellcome Trust/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2017	2
2018	3
2019	7
2020	1
2021	1
2022	1
2023	1
2024	0

1

Bump-and-hole engineering of human polypeptide N-acetylgalactosamine transferases to dissect their protein substrates and glycosylation sites in cells.

Calle B, Gonzalez-Rodriguez E, Mahoney KE, Cioce A, Bineva-Todd G, Tastan OY, Roustan C, Flynn H, Malaker SA, Schumann B. Calle B, et al. STAR Protoc. 2023 Mar 17;4(1):101974. doi: 10.1016/j.xpro.2022.101974. Epub 2023 Jan 11. STAR Protoc. 2023. PMID: 36633947 Free PMC article.

2

Expression of a novel mycobacterial phosphodiesterase successfully lowers cAMP levels resulting in reduced tolerance to cell wall-targeting antimicrobials.

Thomson M, Liu Y, Nunta K, Cheyne A, Fernandes N, Williams R, Garza-Garcia A, Larrouy-Maumus G. Thomson M, et al. J Biol Chem. 2022 Aug;298(8):102151. doi: 10.1016/j.jbc.2022.102151. Epub 2022 Jun 17. J Biol Chem. 2022. PMID: 35718063 Free PMC article.

3

Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B.

Bailey J, Douglas H, Masino L, de Carvalho LPS, Argyrou A. Bailey J, et al. Biochemistry. 2021 Nov 30;60(47):3621-3632. doi: 10.1021/acs.biochem.1c00672. Epub 2021 Nov 15. Biochemistry. 2021. PMID: 34780697 Free PMC article.

4

D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.

de Chiara C, Homšak M, Prosser GA, Douglas HL, Garza-Garcia A, Kelly G, Purkiss AG, Tate EW, de Carvalho LPS. de Chiara C, et al. Nat Chem Biol. 2020 Jun;16(6):686-694. doi: 10.1038/s41589-020-0498-9. Epub 2020 Mar 16. Nat Chem Biol. 2020. PMID: 32203411 Free PMC article.

5

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors.

Kishk SM, McLean KJ, Sood S, Smith D, Evans JWD, Helal MA, Gomaa MS, Salama I, Mostafa SM, de Carvalho LPS, Levy CW, Munro AW, Simons C. Kishk SM, et al. ChemistryOpen. 2019 Jul 23;8(7):995-1011. doi: 10.1002/open.201900227. eCollection 2019 Jul. ChemistryOpen. 2019. PMID: 31367508 Free PMC article.

6

An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism.

Wang H, Fedorov AA, Fedorov EV, Hunt DM, Rodgers A, Douglas HL, Garza-Garcia A, Bonanno JB, Almo SC, de Carvalho LPS. Wang H, et al. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15907-15913. doi: 10.1073/pnas.1906606116. Epub 2019 Jul 18. Proc Natl Acad Sci U S A. 2019. PMID: 31320588 Free PMC article.

7

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1.

Kishk SM, McLean KJ, Sood S, Helal MA, Gomaa MS, Salama I, Mostafa SM, de Carvalho LPS, Munro AW, Simons C. Kishk SM, et al. Bioorg Med Chem. 2019 Apr 15;27(8):1546-1561. doi: 10.1016/j.bmc.2019.02.051. Epub 2019 Feb 27. Bioorg Med Chem. 2019. PMID: 30837169 Free PMC article.

8

"Salmonella, meet mycobacteria.".

Lovell-Read SR, de Carvalho LPS. Lovell-Read SR, et al. J Exp Med. 2019 Apr 1;216(4):721-722. doi: 10.1084/jem.20190065. Epub 2019 Mar 1. J Exp Med. 2019. PMID: 30824477 Free PMC article.

9

An NAD⁺ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.

Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Svergun DI, Schnappinger D, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O. Freire DM, et al. Mol Cell. 2019 Mar 21;73(6):1282-1291.e8. doi: 10.1016/j.molcel.2019.01.028. Epub 2019 Feb 18. Mol Cell. 2019. PMID: 30792174 Free PMC article.

10

Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification.

van der Beek SL, Zorzoli A, Çanak E, Chapman RN, Lucas K, Meyer BH, Evangelopoulos D, de Carvalho LPS, Boons GJ, Dorfmueller HC, van Sorge NM. van der Beek SL, et al. Mol Microbiol. 2019 Apr;111(4):951-964. doi: 10.1111/mmi.14197. Epub 2019 Jan 31. Mol Microbiol. 2019. PMID: 30600561 Free PMC article.

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