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Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. Zhang W, et al. Science. 2015 Jun 5;348(6239):1160-3. doi: 10.1126/science.aaa1356. Epub 2015 Apr 30. Science. 2015. PMID: 25931448 Free PMC article.
Selective elimination of mitochondrial mutations in the germline by genome editing.
Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC. Reddy P, et al. Cell. 2015 Apr 23;161(3):459-469. doi: 10.1016/j.cell.2015.03.051. Cell. 2015. PMID: 25910206 Free PMC article.
Stem cells. Holding your breath for longevity.
Ocampo A, Izpisua Belmonte JC. Ocampo A, et al. Science. 2015 Mar 20;347(6228):1319-20. doi: 10.1126/science.aaa9608. Science. 2015. PMID: 25792319 Free PMC article. No abstract available.