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Targeting Insulin-Degrading Enzyme in Insulin Clearance.
Leissring MA, González-Casimiro CM, Merino B, Suire CN, Perdomo G. Leissring MA, et al. Int J Mol Sci. 2021 Feb 24;22(5):2235. doi: 10.3390/ijms22052235. Int J Mol Sci. 2021. PMID: 33668109 Free PMC article. Review.
Hepatic insulin clearance, a physiological process that in response to nutritional cues clears ~50-80% of circulating insulin, is emerging as an important factor in our understanding of the pathogenesis of type 2 diabetes mellitus (T2DM). Insulin-degra …
Hepatic insulin clearance, a physiological process that in response to nutritional cues clears ~50-80% of circulating insulin, is emerging a …
Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme.
González-Casimiro CM, Merino B, Casanueva-Álvarez E, Postigo-Casado T, Cámara-Torres P, Fernández-Díaz CM, Leissring MA, Cózar-Castellano I, Perdomo G. González-Casimiro CM, et al. Biomedicines. 2021 Jan 17;9(1):86. doi: 10.3390/biomedicines9010086. Biomedicines. 2021. PMID: 33477364 Free PMC article. Review.
Insulin proteostasis and insulin sensitivity have both been highlighted as targets controlling blood sugar levels in type 2 diabetes, so a clearer understanding the physiological functions of IDE in pancreas and liver could led to the development of no …
Insulin proteostasis and insulin sensitivity have both been highlighted as targets controlling blood sugar levels in type 2 …