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Legacy data sharing to improve drug safety assessment: the eTOX project.
Sanz F, Pognan F, Steger-Hartmann T, Díaz C; eTOX; Cases M, Pastor M, Marc P, Wichard J, Briggs K, Watson DK, Kleinöder T, Yang C, Amberg A, Beaumont M, Brookes AJ, Brunak S, Cronin MTD, Ecker GF, Escher S, Greene N, Guzmán A, Hersey A, Jacques P, Lammens L, Mestres J, Muster W, Northeved H, Pinches M, Saiz J, Sajot N, Valencia A, van der Lei J, Vermeulen NPE, Vock E, Wolber G, Zamora I. Sanz F, et al. Among authors: escher s. Nat Rev Drug Discov. 2017 Dec;16(12):811-812. doi: 10.1038/nrd.2017.177. Epub 2017 Oct 13. Nat Rev Drug Discov. 2017. PMID: 29026211 Free article.
Curated human hyperbilirubinemia data and the respective OATP1B1 and 1B3 inhibition predictions.
Kotsampasakou E, Escher SE, Ecker GF. Kotsampasakou E, et al. Data Brief. 2017 Feb 10;11:204-207. doi: 10.1016/j.dib.2017.02.009. eCollection 2017 Apr. Data Brief. 2017. PMID: 28243614 Free PMC article.
These data originate from the research article "Linking organic anion transporting polypeptide 1b1 and 1b3 (oatp1b1 and oatp1b3) interaction profiles to hepatotoxicity- the hyperbilirubinemia use case" (E. Kotsampasakou, S.E. Escher, G.F. Ecker, 2017) [1]. We furthe …
These data originate from the research article "Linking organic anion transporting polypeptide 1b1 and 1b3 (oatp1b1 and oatp1b3) interaction …
Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop.
Ellison CA, Blackburn KL, Carmichael PL, Clewell HJ 3rd, Cronin MTD, Desprez B, Escher SE, Ferguson SS, Grégoire S, Hewitt NJ, Hollnagel HM, Klaric M, Patel A, Salhi S, Schepky A, Schmitt BG, Wambaugh JF, Worth A. Ellison CA, et al. Among authors: escher se. Regul Toxicol Pharmacol. 2019 Apr;103:63-72. doi: 10.1016/j.yrtph.2019.01.016. Epub 2019 Jan 15. Regul Toxicol Pharmacol. 2019. PMID: 30653989 Free PMC article. Review.
Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology.
Rovida C, Barton-Maclaren T, Benfenati E, Caloni F, Chandrasekera PC, Chesné C, Cronin MTD, De Knecht J, Dietrich DR, Escher SE, Fitzpatrick S, Flannery B, Herzler M, Hougaard Bennekou S, Hubesch B, Kamp H, Kisitu J, Kleinstreuer N, Kovarich S, Leist M, Maertens A, Nugent K, Pallocca G, Pastor M, Patlewicz G, Pavan M, Presgrave O, Smirnova L, Schwarz M, Yamada T, Hartung T. Rovida C, et al. Among authors: escher se. ALTEX. 2020;37(4):579-606. doi: 10.14573/altex.1912181. Epub 2020 Apr 30. ALTEX. 2020. PMID: 32369604 Free PMC article.
Adverse outcome pathways: opportunities, limitations and open questions.
Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG. Leist M, et al. Among authors: escher s. Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19. Arch Toxicol. 2017. PMID: 29051992 Review.
Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project.
Escher SE, Kamp H, Bennekou SH, Bitsch A, Fisher C, Graepel R, Hengstler JG, Herzler M, Knight D, Leist M, Norinder U, Ouédraogo G, Pastor M, Stuard S, White A, Zdrazil B, van de Water B, Kroese D. Escher SE, et al. Arch Toxicol. 2019 Dec;93(12):3643-3667. doi: 10.1007/s00204-019-02591-7. Epub 2019 Nov 28. Arch Toxicol. 2019. PMID: 31781791
Evaluation of inhalation TTC values with the database RepDose.
Escher SE, Tluczkiewicz I, Batke M, Bitsch A, Melber C, Kroese ED, Buist HE, Mangelsdorf I. Escher SE, et al. Regul Toxicol Pharmacol. 2010 Nov;58(2):259-74. doi: 10.1016/j.yrtph.2010.06.009. Epub 2010 Jun 23. Regul Toxicol Pharmacol. 2010. PMID: 20600457
186 results