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Infection-derived lipids elicit an immune deficiency circuit in arthropods.
Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH. Shaw DK, et al. Among authors: ernst rk. Nat Commun. 2017 Feb 14;8:14401. doi: 10.1038/ncomms14401. Nat Commun. 2017. PMID: 28195158 Free PMC article.
The TLR4 antagonist Eritoran protects mice from lethal influenza infection.
Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp CL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DP, Gusovsky F, Blanco JC, Vogel SN. Shirey KA, et al. Among authors: ernst rk. Nature. 2013 May 23;497(7450):498-502. doi: 10.1038/nature12118. Epub 2013 May 1. Nature. 2013. PMID: 23636320 Free PMC article.
Type IV pili promote early biofilm formation by Clostridium difficile.
Maldarelli GA, Piepenbrink KH, Scott AJ, Freiberg JA, Song Y, Achermann Y, Ernst RK, Shirtliff ME, Sundberg EJ, Donnenberg MS, von Rosenvinge EC. Maldarelli GA, et al. Among authors: ernst rk. Pathog Dis. 2016 Aug;74(6):ftw061. doi: 10.1093/femspd/ftw061. Epub 2016 Jun 30. Pathog Dis. 2016. PMID: 27369898 Free PMC article.
Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship.
Scott AJ, Oyler BL, Goodlett DR, Ernst RK. Scott AJ, et al. Among authors: ernst rk. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Nov;1862(11):1439-1450. doi: 10.1016/j.bbalip.2017.01.004. Epub 2017 Jan 17. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. PMID: 28108356 Free PMC article. Review.
Host-based lipid inflammation drives pathogenesis in Francisella infection.
Scott AJ, Post JM, Lerner R, Ellis SR, Lieberman J, Shirey KA, Heeren RMA, Bindila L, Ernst RK. Scott AJ, et al. Among authors: ernst rk. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12596-12601. doi: 10.1073/pnas.1712887114. Epub 2017 Nov 6. Proc Natl Acad Sci U S A. 2017. PMID: 29109289 Free PMC article.
237 results