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Fragment-to-Lead Medicinal Chemistry Publications in 2020.
de Esch IJP, Erlanson DA, Jahnke W, Johnson CN, Walsh L. de Esch IJP, et al. Among authors: erlanson da. J Med Chem. 2022 Jan 13;65(1):84-99. doi: 10.1021/acs.jmedchem.1c01803. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928151 Free PMC article. Review.
Fragment-based drug discovery.
Erlanson DA, McDowell RS, O'Brien T. Erlanson DA, et al. J Med Chem. 2004 Jul 1;47(14):3463-82. doi: 10.1021/jm040031v. J Med Chem. 2004. PMID: 15214773 Review. No abstract available.
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Erlanson DA, Arndt JW, Cancilla MT, Cao K, Elling RA, English N, Friedman J, Hansen SK, Hession C, Joseph I, Kumaravel G, Lee WC, Lind KE, McDowell RS, Miatkowski K, Nguyen C, Nguyen TB, Park S, Pathan N, Penny DM, Romanowski MJ, Scott D, Silvian L, Simmons RL, Tangonan BT, Yang W, Sun L. Erlanson DA, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3078-83. doi: 10.1016/j.bmcl.2011.03.032. Epub 2011 Mar 17. Bioorg Med Chem Lett. 2011. PMID: 21459573
Learning from PAINful lessons.
Erlanson DA. Erlanson DA. J Med Chem. 2015 Mar 12;58(5):2088-90. doi: 10.1021/acs.jmedchem.5b00294. Epub 2015 Feb 24. J Med Chem. 2015. PMID: 25710486
Twenty years on: the impact of fragments on drug discovery.
Erlanson DA, Fesik SW, Hubbard RE, Jahnke W, Jhoti H. Erlanson DA, et al. Nat Rev Drug Discov. 2016 Sep;15(9):605-619. doi: 10.1038/nrd.2016.109. Epub 2016 Jul 15. Nat Rev Drug Discov. 2016. PMID: 27417849 Review.
46 results