Emanuelsson C - Search Results

1

Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation.

Nagaraj M, Najarzadeh Z, Pansieri J, Biverstål H, Musteikyte G, Smirnovas V, Matthews S, Emanuelsson C, Johansson J, Buxbaum JN, Morozova-Roche L, Otzen DE. Nagaraj M, et al. Among authors: emanuelsson c. Chem Sci. 2021 Dec 13;13(2):536-553. doi: 10.1039/d1sc05790a. eCollection 2022 Jan 5. Chem Sci. 2021. PMID: 35126986 Free PMC article.

2

The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State.

Carlsson A, Axell E, Emanuelsson C, Olsson U, Linse S. Carlsson A, et al. Among authors: emanuelsson c. ACS Chem Neurosci. 2024 May 1;15(9):1732-1737. doi: 10.1021/acschemneuro.4c00120. Epub 2024 Apr 19. ACS Chem Neurosci. 2024. PMID: 38640082 Free PMC article.

3

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.

Arosio P, Michaels TC, Linse S, Månsson C, Emanuelsson C, Presto J, Johansson J, Vendruscolo M, Dobson CM, Knowles TP. Arosio P, et al. Among authors: emanuelsson c. Nat Commun. 2016 Mar 24;7:10948. doi: 10.1038/ncomms10948. Nat Commun. 2016. PMID: 27009901 Free PMC article.

4

Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation.

Österlund N, Lundqvist M, Ilag LL, Gräslund A, Emanuelsson C. Österlund N, et al. Among authors: emanuelsson c. J Biol Chem. 2020 Jun 12;295(24):8135-8144. doi: 10.1074/jbc.RA120.013459. Epub 2020 Apr 29. J Biol Chem. 2020. PMID: 32350108 Free PMC article.

5

The C-terminal domain of the antiamyloid chaperone DNAJB6 binds to amyloid-β peptide fibrils and inhibits secondary nucleation.

Österlund N, Frankel R, Carlsson A, Thacker D, Karlsson M, Matus V, Gräslund A, Emanuelsson C, Linse S. Österlund N, et al. Among authors: emanuelsson c. J Biol Chem. 2023 Nov;299(11):105317. doi: 10.1016/j.jbc.2023.105317. Epub 2023 Oct 4. J Biol Chem. 2023. PMID: 37797698 Free PMC article.

6

DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios.

Månsson C, Kakkar V, Monsellier E, Sourigues Y, Härmark J, Kampinga HH, Melki R, Emanuelsson C. Månsson C, et al. Among authors: emanuelsson c. Cell Stress Chaperones. 2014 Mar;19(2):227-39. doi: 10.1007/s12192-013-0448-5. Epub 2013 Aug 1. Cell Stress Chaperones. 2014. PMID: 23904097 Free PMC article.

7

The chloroplast-localized small heat shock protein Hsp21 associates with the thylakoid membranes in heat-stressed plants.

Bernfur K, Rutsdottir G, Emanuelsson C. Bernfur K, et al. Among authors: emanuelsson c. Protein Sci. 2017 Sep;26(9):1773-1784. doi: 10.1002/pro.3213. Epub 2017 Jun 26. Protein Sci. 2017. PMID: 28608391 Free PMC article.

8

Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.

Månsson C, van Cruchten RTP, Weininger U, Yang X, Cukalevski R, Arosio P, Dobson CM, Knowles T, Akke M, Linse S, Emanuelsson C. Månsson C, et al. Among authors: emanuelsson c. Biochemistry. 2018 Aug 14;57(32):4891-4902. doi: 10.1021/acs.biochem.8b00353. Epub 2018 Jul 30. Biochemistry. 2018. PMID: 30024736

9

Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.

Månsson C, Arosio P, Hussein R, Kampinga HH, Hashem RM, Boelens WC, Dobson CM, Knowles TP, Linse S, Emanuelsson C. Månsson C, et al. Among authors: emanuelsson c. J Biol Chem. 2014 Nov 7;289(45):31066-76. doi: 10.1074/jbc.M114.595124. Epub 2014 Sep 12. J Biol Chem. 2014. PMID: 25217638 Free PMC article.

10

Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface.

Söderberg CAG, Månsson C, Bernfur K, Rutsdottir G, Härmark J, Rajan S, Al-Karadaghi S, Rasmussen M, Höjrup P, Hebert H, Emanuelsson C. Söderberg CAG, et al. Among authors: emanuelsson c. Sci Rep. 2018 Mar 26;8(1):5199. doi: 10.1038/s41598-018-23035-9. Sci Rep. 2018. PMID: 29581438 Free PMC article.

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