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Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system.
Weigert A, Zheng X, Nenzel A, Turkowski K, Günther S, Strack E, Sirait-Fischer E, Elwakeel E, Kur IM, Nikam VS, Valasarajan C, Winter H, Wissgott A, Voswinkel R, Grimminger F, Brüne B, Seeger W, Pullamsetti SS, Savai R. Weigert A, et al. Among authors: elwakeel e. Nat Commun. 2022 Oct 14;13(1):6078. doi: 10.1038/s41467-022-33458-8. Nat Commun. 2022. PMID: 36241617 Free PMC article.
PGE2 in fibrosis and cancer: Insights into fibroblast activation.
Elwakeel E, Brüne B, Weigert A. Elwakeel E, et al. Prostaglandins Other Lipid Mediat. 2019 Aug;143:106339. doi: 10.1016/j.prostaglandins.2019.106339. Epub 2019 May 14. Prostaglandins Other Lipid Mediat. 2019. PMID: 31100473 Review.
S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β.
Weichand B, Popp R, Dziumbla S, Mora J, Strack E, Elwakeel E, Frank AC, Scholich K, Pierre S, Syed SN, Olesch C, Ringleb J, Ören B, Döring C, Savai R, Jung M, von Knethen A, Levkau B, Fleming I, Weigert A, Brüne B. Weichand B, et al. Among authors: elwakeel e. J Exp Med. 2017 Sep 4;214(9):2695-2713. doi: 10.1084/jem.20160392. Epub 2017 Jul 24. J Exp Med. 2017. PMID: 28739604 Free PMC article.
Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis.
Elwakeel E, Brüggemann M, Wagih J, Lityagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten FR, Zarnack K, Brüne B, Weigert A. Elwakeel E, et al. Cancer Res. 2022 Apr 1;82(7):1380-1395. doi: 10.1158/0008-5472.CAN-21-2116. Cancer Res. 2022. PMID: 35105690
Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.
Kesavan R, Frömel T, Zukunft S, Laban H, Geyer A, Naeem Z, Heidler J, Wittig I, Elwakeel E, Brüne B, Weigert A, Popp R, Fleming I. Kesavan R, et al. Among authors: elwakeel e. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5923-5930. doi: 10.1073/pnas.1921381117. Epub 2020 Mar 2. Proc Natl Acad Sci U S A. 2020. PMID: 32123095 Free PMC article.
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer.
Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR. Nicolas AM, et al. Among authors: elwakeel e. Cancer Cell. 2022 Feb 14;40(2):168-184.e13. doi: 10.1016/j.ccell.2022.01.004. Epub 2022 Feb 3. Cancer Cell. 2022. PMID: 35120600 Free article.
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH. Schwiebs A, et al. Among authors: elwakeel e. Oncogene. 2019 Jun;38(24):4788-4803. doi: 10.1038/s41388-019-0758-x. Epub 2019 Feb 28. Oncogene. 2019. PMID: 30816345
28 results