Elkamhawy A - Search Results

1

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.

El-Kalyoubi S, Khalifa MM, Abo-Elfadl MT, El-Sayed AA, Elkamhawy A, Lee K, Al-Karmalawy AA. El-Kalyoubi S, et al. Among authors: elkamhawy a. J Enzyme Inhib Med Chem. 2023 Aug 17;38(1):2242714. doi: 10.1080/14756366.2023.2242714. J Enzyme Inhib Med Chem. 2023. PMID: 37592917 Free PMC article.

2

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamidesAQ3 as carbonic anhydrase isoforms I and II inhibitors.

Al-Sanea MM, Elkamhawy A, Paik S, Bua S, Ha Lee S, Abdelgawad MA, Roh EJ, Eldehna WM, Supuran CT. Al-Sanea MM, et al. Among authors: elkamhawy a. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1457-1464. doi: 10.1080/14756366.2019.1652282. J Enzyme Inhib Med Chem. 2019. PMID: 31411080 Free PMC article.

3

Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights.

Al-Sanea MM, Elkamhawy A, Paik S, Lee K, El Kerdawy AM, Syed Nasir Abbas B, Joo Roh E, Eldehna WM, Elshemy HAH, Bakr RB, Ali Farahat I, Alzarea AI, Alzarea SI, Alharbi KS, Abdelgawad MA. Al-Sanea MM, et al. Among authors: elkamhawy a. Bioorg Med Chem. 2020 Jul 1;28(13):115525. doi: 10.1016/j.bmc.2020.115525. Epub 2020 Apr 25. Bioorg Med Chem. 2020. PMID: 32371117

4

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.

Elkamhawy A, Paik S, Kim HJ, Park JH, Londhe AM, Lee K, Pae AN, Park KD, Roh EJ. Elkamhawy A, et al. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1568-1580. doi: 10.1080/14756366.2020.1800666. J Enzyme Inhib Med Chem. 2020. PMID: 32752896 Free PMC article.

5

Structure Activity Relationship of Key Heterocyclic Anti-Angiogenic Leads of Promising Potential in the Fight against Cancer.

Nada H, Elkamhawy A, Lee K. Nada H, et al. Among authors: elkamhawy a. Molecules. 2021 Jan 21;26(3):553. doi: 10.3390/molecules26030553. Molecules. 2021. PMID: 33494492 Free PMC article. Review.

6

The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer.

Elkamhawy A, Lu Q, Nada H, Woo J, Quan G, Lee K. Elkamhawy A, et al. Int J Mol Sci. 2021 Jun 18;22(12):6535. doi: 10.3390/ijms22126535. Int J Mol Sci. 2021. PMID: 34207360 Free PMC article. Review.

7

New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011-2021) focussing on structure-activity relationship (SAR) and docking insights.

Elkamhawy A, Ali EMH, Lee K. Elkamhawy A, et al. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1574-1602. doi: 10.1080/14756366.2021.1937143. J Enzyme Inhib Med Chem. 2021. PMID: 34233563 Free PMC article. Review.

8

Discovery of novel and potent safinamide-based derivatives as highly selective hMAO-B inhibitors for treatment of Parkinson's disease (PD): Design, synthesis, in vitro, in vivo and in silico biological studies.

Elkamhawy A, Paik S, Park JH, Kim HJ, Hassan AHE, Lee K, Park KD, Roh EJ. Elkamhawy A, et al. Bioorg Chem. 2021 Oct;115:105233. doi: 10.1016/j.bioorg.2021.105233. Epub 2021 Aug 2. Bioorg Chem. 2021. PMID: 34390968

9

Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening.

Elkamhawy A, Ammar UM, Paik S, Abdellattif MH, Elsherbeny MH, Lee K, Roh EJ. Elkamhawy A, et al. Molecules. 2021 Sep 1;26(17):5324. doi: 10.3390/molecules26175324. Molecules. 2021. PMID: 34500757 Free PMC article.

10

Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action.

Elkamhawy A, Kim HJ, Elsherbeny MH, Paik S, Park JH, Gotina L, Abdellattif MH, Gouda NA, Cho J, Lee K, Nim Pae A, Park KD, Roh EJ. Elkamhawy A, et al. Bioorg Chem. 2021 Nov;116:105352. doi: 10.1016/j.bioorg.2021.105352. Epub 2021 Sep 11. Bioorg Chem. 2021. PMID: 34562673

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