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HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner.
Turgu B, Zhang F, El-Naggar A, Negri GL, Kogler M, Tortola L, Johnson F, Ng T, Li A, Yapp D, Lockwood W, Martinez D, Maris JM, Daugaard M, Penninger JM, Hughes CS, Sorensen PH. Turgu B, et al. Oncogene. 2021 Mar;40(11):1988-2001. doi: 10.1038/s41388-021-01680-1. Epub 2021 Feb 18. Oncogene. 2021. PMID: 33603169 Free PMC article.
HACE1 is a potential tumor suppressor in osteosarcoma.
El-Naggar AM, Clarkson PW, Negri GL, Turgu B, Zhang F, Anglesio MS, Sorensen PH. El-Naggar AM, et al. Cell Death Dis. 2019 Jan 8;10(1):21. doi: 10.1038/s41419-018-1276-4. Cell Death Dis. 2019. PMID: 30622235 Free PMC article.
HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.
Kogler M, Tortola L, Negri GL, Leopoldi A, El-Naggar AM, Mereiter S, Gomez-Diaz C, Nitsch R, Tortora D, Kavirayani AM, Gapp BV, Rao S, Uribesalgo I, Hoffmann D, Cikes D, Novatchkova M, Williams DA, Trent JM, Ikeda F, Daugaard M, Hagelkruys A, Sorensen PH, Penninger JM. Kogler M, et al. Cancer Res. 2020 Jul 15;80(14):3009-3022. doi: 10.1158/0008-5472.CAN-19-2270. Epub 2020 May 4. Cancer Res. 2020. PMID: 32366477 Free PMC article.
Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.
El-Naggar AM, Somasekharan SP, Wang Y, Cheng H, Negri GL, Pan M, Wang XQ, Delaidelli A, Rafn B, Cran J, Zhang F, Zhang H, Colborne S, Gleave M, Mandinova A, Kedersha N, Hughes CS, Surdez D, Delattre O, Wang Y, Huntsman DG, Morin GB, Sorensen PH. El-Naggar AM, et al. EMBO Rep. 2019 Dec 5;20(12):e48375. doi: 10.15252/embr.201948375. Epub 2019 Oct 31. EMBO Rep. 2019. PMID: 31668005 Free PMC article.
Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma.
Zhang HF, Hughes CS, Li W, He JZ, Surdez D, El-Naggar AM, Cheng H, Prudova A, Delaidelli A, Negri GL, Li X, Ørum-Madsen MS, Lizardo MM, Oo HZ, Colborne S, Shyp T, Scopim-Ribeiro R, Hammond CA, Dhez AC, Langman S, Lim JKM, Kung SHY, Li A, Steino A, Daugaard M, Parker SJ, Geltink RIK, Orentas RJ, Xu LY, Morin GB, Delattre O, Dimitrov DS, Sorensen PH. Zhang HF, et al. Cancer Discov. 2021 Nov;11(11):2884-2903. doi: 10.1158/2159-8290.CD-20-1690. Epub 2021 May 21. Cancer Discov. 2021. PMID: 34021002 Free PMC article.
Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma.
Mooney B, Negri GL, Shyp T, Delaidelli A, Zhang HF, Spencer Miko SE, Weiner AK, Radaoui AB, Shraim R, Lizardo MM, Hughes CS, Li A, El-Naggar AM, Rouleau M, Li W, Dimitrov DS, Kurmasheva RT, Houghton PJ, Diskin SJ, Maris JM, Morin GB, Sorensen PH. Mooney B, et al. Clin Cancer Res. 2024 Mar 1;30(5):1022-1037. doi: 10.1158/1078-0432.CCR-23-2187. Clin Cancer Res. 2024. PMID: 37812652 Free PMC article.
1,081 results