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Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists.
Prieto-Díaz R, González-Gómez M, Fojo-Carballo H, Azuaje J, El Maatougui A, Majellaro M, Loza MI, Brea J, Fernández-Dueñas V, Paleo MR, Díaz-Holguín A, Garcia-Pinel B, Mallo-Abreu A, Estévez JC, Andújar-Arias A, García-Mera X, Gomez-Tourino I, Ciruela F, Salas CO, Gutiérrez-de-Terán H, Sotelo E. Prieto-Díaz R, et al. Among authors: el maatougui a. J Med Chem. 2023 Jan 12;66(1):890-912. doi: 10.1021/acs.jmedchem.2c01768. Epub 2022 Dec 14. J Med Chem. 2023. PMID: 36517209 Free PMC article.
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition.
Majellaro M, Jespers W, Crespo A, Núñez MJ, Novio S, Azuaje J, Prieto-Díaz R, Gioé C, Alispahic B, Brea J, Loza MI, Freire-Garabal M, Garcia-Santiago C, Rodríguez-García C, García-Mera X, Caamaño O, Fernandez-Masaguer C, Sardina JF, Stefanachi A, El Maatougui A, Mallo-Abreu A, Åqvist J, Gutiérrez-de-Terán H, Sotelo E. Majellaro M, et al. Among authors: el maatougui a. J Med Chem. 2021 Jan 14;64(1):458-480. doi: 10.1021/acs.jmedchem.0c01431. Epub 2020 Dec 29. J Med Chem. 2021. PMID: 33372800
Ugi-based approaches to quinoxaline libraries.
Azuaje J, El Maatougui A, García-Mera X, Sotelo E. Azuaje J, et al. Among authors: el maatougui a. ACS Comb Sci. 2014 Aug 11;16(8):403-11. doi: 10.1021/co500036n. Epub 2014 May 14. ACS Comb Sci. 2014. PMID: 24800648
Multicomponent assembly of diverse pyrazin-2(1H)-one chemotypes.
Azuaje J, El Maatougui A, Pérez-Rubio JM, Coelho A, Fernández F, Sotelo E. Azuaje J, et al. Among authors: el maatougui a. J Org Chem. 2013 May 3;78(9):4402-9. doi: 10.1021/jo4003163. Epub 2013 Apr 12. J Org Chem. 2013. PMID: 23551216
14 results