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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL. Cardozo AK, et al. Among authors: eizirik dl. Diabetes. 2005 Feb;54(2):452-61. doi: 10.2337/diabetes.54.2.452. Diabetes. 2005. PMID: 15677503
Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass.
Nguidjoe E, Sokolow S, Bigabwa S, Pachera N, D'Amico E, Allagnat F, Vanderwinden JM, Sener A, Manto M, Depreter M, Mast J, Joanny G, Montanya E, Rahier J, Cardozo AK, Eizirik DL, Schurmans S, Herchuelz A. Nguidjoe E, et al. Among authors: eizirik dl. Diabetes. 2011 Aug;60(8):2076-85. doi: 10.2337/db10-0924. Epub 2011 Jun 9. Diabetes. 2011. PMID: 21659499 Free PMC article.
418 results