Egawa D - Search Results

1

α-Pyrrolidinononanophenone derivatives induce differentiated SH-SY5Y neuroblastoma cell apoptosis via reduction of antioxidant capacity: Involvement of NO depletion and inactivation of Nrf2/HO1 signaling pathway.

Sakai Y, Egawa D, Hattori J, Morikawa Y, Suenami K, Takayama T, Nagai A, Michiue T, Ikari A, Matsunaga T. Sakai Y, et al. Among authors: egawa d. Neurotoxicology. 2024 Jan;100:3-15. doi: 10.1016/j.neuro.2023.11.010. Epub 2023 Nov 30. Neurotoxicology. 2024. PMID: 38040126

2

Covalent Modifier Discovery Using Hydrogen/Deuterium Exchange-Mass Spectrometry.

Kojima H, Yanagi R, Higuchi E, Yoshizawa M, Shimodaira T, Kumagai M, Kyoya T, Sekine M, Egawa D, Ohashi N, Ishida H, Yamamoto K, Itoh T. Kojima H, et al. Among authors: egawa d. J Med Chem. 2023 Apr 13;66(7):4827-4839. doi: 10.1021/acs.jmedchem.2c01986. Epub 2023 Mar 30. J Med Chem. 2023. PMID: 36994595

3

Involvement of a Cluster of Basic Amino Acids in Phosphorylation-Dependent Functional Repression of the Ceramide Transport Protein CERT.

Goto A, Egawa D, Tomishige N, Yamaji T, Shimasaki K, Kumagai K, Hanada K. Goto A, et al. Among authors: egawa d. Int J Mol Sci. 2022 Aug 2;23(15):8576. doi: 10.3390/ijms23158576. Int J Mol Sci. 2022. PMID: 35955719 Free PMC article.

4

Structural Insights into the Loss-of-Function R288H Mutant of Human PPARγ.

Egawa D, Ogiso T, Nishikata K, Yamamoto K, Itoh T. Egawa D, et al. Biol Pharm Bull. 2021;44(9):1196-1201. doi: 10.1248/bpb.b21-00253. Biol Pharm Bull. 2021. PMID: 34471047 Free article.

5

Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif.

Sugiki T, Egawa D, Kumagai K, Kojima C, Fujiwara T, Takeuchi K, Shimada I, Hanada K, Takahashi H. Sugiki T, et al. Among authors: egawa d. J Biol Chem. 2018 Jul 13;293(28):11206-11217. doi: 10.1074/jbc.RA118.002465. Epub 2018 May 30. J Biol Chem. 2018. PMID: 29848549 Free PMC article.

6

SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity.

Egawa D, Itoh T, Kato A, Kataoka S, Anami Y, Yamamoto K. Egawa D, et al. Bioorg Med Chem. 2017 Jan 15;25(2):568-574. doi: 10.1016/j.bmc.2016.11.020. Epub 2016 Nov 14. Bioorg Med Chem. 2017. PMID: 27890450

7

Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by Hybrid Approach Combining Small-Angle X-ray Scattering and Molecular Dynamics.

Anami Y, Shimizu N, Ekimoto T, Egawa D, Itoh T, Ikeguchi M, Yamamoto K. Anami Y, et al. Among authors: egawa d. J Med Chem. 2016 Sep 8;59(17):7888-900. doi: 10.1021/acs.jmedchem.6b00682. Epub 2016 Aug 26. J Med Chem. 2016. PMID: 27535484

8

17-OxoDHA Is a PPARα/γ Dual Covalent Modifier and Agonist.

Egawa D, Itoh T, Akiyama Y, Saito T, Yamamoto K. Egawa D, et al. ACS Chem Biol. 2016 Sep 16;11(9):2447-55. doi: 10.1021/acschembio.6b00338. Epub 2016 Jul 1. ACS Chem Biol. 2016. PMID: 27337155

9

Helix12-Stabilization Antagonist of Vitamin D Receptor.

Kato A, Itoh T, Anami Y, Egawa D, Yamamoto K. Kato A, et al. Among authors: egawa d. Bioconjug Chem. 2016 Jul 20;27(7):1750-61. doi: 10.1021/acs.bioconjchem.6b00246. Epub 2016 Jun 27. Bioconjug Chem. 2016. PMID: 27294600

10

Characterization of covalent bond formation between PPARγ and oxo-fatty acids.

Egawa D, Itoh T, Yamamoto K. Egawa D, et al. Bioconjug Chem. 2015 Apr 15;26(4):690-8. doi: 10.1021/acs.bioconjchem.5b00021. Epub 2015 Mar 26. Bioconjug Chem. 2015. PMID: 25785518

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