Egan W - Search Results

1

Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.

Pearlstein RA, MacCannell KA, Erdemli G, Yeola S, Helmlinger G, Hu QY, Farid R, Egan W, Whitebread S, Springer C, Beck J, Wang HR, Maciejewski M, Urban L, Duca JS. Pearlstein RA, et al. Among authors: egan w. Curr Top Med Chem. 2016;16(16):1792-818. doi: 10.2174/1568026616666160315142156. Curr Top Med Chem. 2016. PMID: 26975508 Review.

2

Can we use docking and scoring for hit-to-lead optimization?

Enyedy IJ, Egan WJ. Enyedy IJ, et al. J Comput Aided Mol Des. 2008 Mar-Apr;22(3-4):161-8. doi: 10.1007/s10822-007-9165-4. Epub 2008 Jan 9. J Comput Aided Mol Des. 2008. PMID: 18183356

3

Prediction of drug absorption using multivariate statistics.

Egan WJ, Merz KM Jr, Baldwin JJ. Egan WJ, et al. J Med Chem. 2000 Oct 19;43(21):3867-77. doi: 10.1021/jm000292e. J Med Chem. 2000. PMID: 11052792

4

In silico prediction of drug safety: despite progress there is abundant room for improvement.

Egan WJ, Zlokarnik G, Grootenhuis PD. Egan WJ, et al. Drug Discov Today Technol. 2004 Dec;1(4):381-7. doi: 10.1016/j.ddtec.2004.11.002. Drug Discov Today Technol. 2004. PMID: 24981618

5

Computation of the physio-chemical properties and data mining of large molecular collections.

Cheng A, Diller DJ, Dixon SL, Egan WJ, Lauri G, Merz KM Jr. Cheng A, et al. J Comput Chem. 2002 Jan 15;23(1):172-83. doi: 10.1002/jcc.1164. J Comput Chem. 2002. PMID: 11913384

6

Prediction of intestinal permeability.

Egan WJ, Lauri G. Egan WJ, et al. Adv Drug Deliv Rev. 2002 Mar 31;54(3):273-89. doi: 10.1016/s0169-409x(02)00004-2. Adv Drug Deliv Rev. 2002. PMID: 11922948 Review.

7

Guiding molecules towards drug-likeness.

Egan WJ, Walters WP, Murcko MA. Egan WJ, et al. Curr Opin Drug Discov Devel. 2002 Jul;5(4):540-9. Curr Opin Drug Discov Devel. 2002. PMID: 12197312 Review.

8

A statistical-based approach to assessing the fidelity of combinatorial libraries encoded with electrophoric molecular tags. Development and application of tag decode-assisted single bead LC/MS analysis.

Dolle RE, Guo J, O'Brien L, Jin Y, Piznik M, Bowman KJ, Li W, Egan WJ, Cavallaro CL, Roughton AL, Zhao Q, Reader JC, Orlowski M, Jacob-Samuel B, Carroll CD. Dolle RE, et al. Among authors: egan wj. J Comb Chem. 2000 Nov-Dec;2(6):716-31. doi: 10.1021/cc000052k. J Comb Chem. 2000. PMID: 11126300

9

Only 1% of Total Knee Arthroplasty Clinical Trials Report Patient Opioid Use Before or After Surgery: A Systematic Review.

Crane P, Morris J, Egan W, Young JL, Nova V, Rhon DI. Crane P, et al. Among authors: egan w. Clin J Pain. 2023 Sep 1;39(9):467-472. doi: 10.1097/AJP.0000000000001139. Clin J Pain. 2023. PMID: 37335227

10

When Treating Coexisting Low Back Pain and Hip Impairments, Focus on the Back: Adding Specific Hip Treatment Does Not Yield Additional Benefits-A Randomized Controlled Trial.

Burns SA, Cleland JA, Rivett DA, O'Hara MC, Egan W, Pandya J, Snodgrass SJ. Burns SA, et al. Among authors: egan w. J Orthop Sports Phys Ther. 2021 Dec;51(12):581-601. doi: 10.2519/jospt.2021.10593. Epub 2021 Nov 16. J Orthop Sports Phys Ther. 2021. PMID: 34784246 Clinical Trial.

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