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DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice.
Senatus L, Egaña-Gorroño L, López-Díez R, Bergaya S, Aranda JF, Amengual J, Arivazhagan L, Manigrasso MB, Yepuri G, Nimma R, Mangar KN, Bernadin R, Zhou B, Gugger PF, Li H, Friedman RA, Theise ND, Shekhtman A, Fisher EA, Ramasamy R, Schmidt AM. Senatus L, et al. Among authors: egana gorrono l. Commun Biol. 2023 Mar 17;6(1):280. doi: 10.1038/s42003-023-04643-2. Commun Biol. 2023. PMID: 36932214 Free PMC article.
Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice.
Manigrasso MB, Rabbani P, Egaña-Gorroño L, Quadri N, Frye L, Zhou B, Reverdatto S, Ramirez LS, Dansereau S, Pan J, Li H, D'Agati VD, Ramasamy R, DeVita RJ, Shekhtman A, Schmidt AM. Manigrasso MB, et al. Among authors: egana gorrono l. Sci Transl Med. 2021 Nov 24;13(621):eabf7084. doi: 10.1126/scitranslmed.abf7084. Epub 2021 Nov 24. Sci Transl Med. 2021. PMID: 34818060 Free PMC article.
Inflammation Meets Metabolism: Roles for the Receptor for Advanced Glycation End Products Axis in Cardiovascular Disease.
Senatus L, MacLean M, Arivazhagan L, Egaña-Gorroño L, López-Díez R, Manigrasso MB, Ruiz HH, Vasquez C, Wilson R, Shekhtman A, Gugger PF, Ramasamy R, Schmidt AM. Senatus L, et al. Among authors: egana gorrono l. Immunometabolism. 2021;3(3):e210024. doi: 10.20900/immunometab20210024. Epub 2021 Jun 2. Immunometabolism. 2021. PMID: 34178389 Free PMC article.
Diabetes and Cardiovascular Complications: The Epidemics Continue.
López-Díez R, Egaña-Gorroño L, Senatus L, Shekhtman A, Ramasamy R, Schmidt AM. López-Díez R, et al. Among authors: egana gorrono l. Curr Cardiol Rep. 2021 Jun 3;23(7):74. doi: 10.1007/s11886-021-01504-4. Curr Cardiol Rep. 2021. PMID: 34081211 Free PMC article. Review.
RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism.
Senatus L, López-Díez R, Egaña-Gorroño L, Liu J, Hu J, Daffu G, Li Q, Rahman K, Vengrenyuk Y, Barrett TJ, Dewan MZ, Guo L, Fuller D, Finn AV, Virmani R, Li H, Friedman RA, Fisher EA, Ramasamy R, Schmidt AM. Senatus L, et al. Among authors: egana gorrono l. JCI Insight. 2020 Jul 9;5(13):e137289. doi: 10.1172/jci.insight.137289. JCI Insight. 2020. PMID: 32641587 Free PMC article.
Receptor for Advanced Glycation End Products (RAGE) and Mechanisms and Therapeutic Opportunities in Diabetes and Cardiovascular Disease: Insights From Human Subjects and Animal Models.
Egaña-Gorroño L, López-Díez R, Yepuri G, Ramirez LS, Reverdatto S, Gugger PF, Shekhtman A, Ramasamy R, Schmidt AM. Egaña-Gorroño L, et al. Front Cardiovasc Med. 2020 Mar 10;7:37. doi: 10.3389/fcvm.2020.00037. eCollection 2020. Front Cardiovasc Med. 2020. PMID: 32211423 Free PMC article. Review.
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