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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Lang J, et al. Among authors: edwards mj. Nat Commun. 2020 Mar 12;11(1):1338. doi: 10.1038/s41467-020-15072-8. Nat Commun. 2020. PMID: 32165633 Free PMC article.
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
Beckmann N, Becker KA, Kadow S, Schumacher F, Kramer M, Kühn C, Schulz-Schaeffer WJ, Edwards MJ, Kleuser B, Gulbins E, Carpinteiro A. Beckmann N, et al. Among authors: edwards mj. Int J Mol Sci. 2019 Dec 11;20(24):6253. doi: 10.3390/ijms20246253. Int J Mol Sci. 2019. PMID: 31835809 Free PMC article.
Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections.
Becker KA, Verhaegh R, Verhasselt HL, Keitsch S, Soddemann M, Wilker B, Wilson GC, Buer J, Ahmad SA, Edwards MJ, Gulbins E. Becker KA, et al. Among authors: edwards mj. Infect Immun. 2021 Jan 19;89(2):e00677-20. doi: 10.1128/IAI.00677-20. Print 2021 Jan 19. Infect Immun. 2021. PMID: 33139382 Free PMC article.
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.
Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Pewzner-Jung Y, et al. Among authors: edwards mj. EMBO Mol Med. 2014 Sep;6(9):1205-14. doi: 10.15252/emmm.201404075. EMBO Mol Med. 2014. PMID: 25085879 Free PMC article.
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice.
Henry BD, Neill DR, Becker KA, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Mühlemann K, Steinmann J, Kleuser B, Japtok L, Luginbühl M, Wolfmeier H, Scherag A, Gulbins E, Kadioglu A, Draeger A, Babiychuk EB. Henry BD, et al. Among authors: edwards mj. Nat Biotechnol. 2015 Jan;33(1):81-8. doi: 10.1038/nbt.3037. Epub 2014 Nov 2. Nat Biotechnol. 2015. PMID: 25362245
Ceramide mediates lung fibrosis in cystic fibrosis.
Ziobro R, Henry B, Edwards MJ, Lentsch AB, Gulbins E. Ziobro R, et al. Among authors: edwards mj. Biochem Biophys Res Commun. 2013 May 17;434(4):705-9. doi: 10.1016/j.bbrc.2013.03.032. Epub 2013 Mar 21. Biochem Biophys Res Commun. 2013. PMID: 23523785 Free PMC article.
1,023 results