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A driving test for oncogenic mutations.
Heppner DE, Beyett TS, Eck MJ. Heppner DE, et al. Among authors: eck mj. J Biol Chem. 2019 Jun 14;294(24):9390-9391. doi: 10.1074/jbc.H119.009452. J Biol Chem. 2019. PMID: 31201242 Free PMC article.
Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Park E, Rawson S, Li K, Kim BW, Ficarro SB, Pino GG, Sharif H, Marto JA, Jeon H, Eck MJ. Park E, et al. Among authors: eck mj. Nature. 2019 Nov;575(7783):545-550. doi: 10.1038/s41586-019-1660-y. Epub 2019 Oct 3. Nature. 2019. PMID: 31581174 Free PMC article.
The protein kinase Akt acts as a coat adaptor in endocytic recycling.
Hsu JW, Bai M, Li K, Yang JS, Chu N, Cole PA, Eck MJ, Li J, Hsu VW. Hsu JW, et al. Among authors: eck mj. Nat Cell Biol. 2020 Aug;22(8):927-933. doi: 10.1038/s41556-020-0530-z. Epub 2020 Jun 15. Nat Cell Biol. 2020. PMID: 32541877 Free PMC article.
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
Wittlinger F, Heppner DE, To C, Günther M, Shin BH, Rana JK, Schmoker AM, Beyett TS, Berger LM, Berger BT, Bauer N, Vasta JD, Corona CR, Robers MB, Knapp S, Jänne PA, Eck MJ, Laufer SA. Wittlinger F, et al. Among authors: eck mj. J Med Chem. 2022 Jan 27;65(2):1370-1383. doi: 10.1021/acs.jmedchem.1c00848. Epub 2021 Oct 20. J Med Chem. 2022. PMID: 34668706 Free PMC article.
Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.
Gero TW, Heppner DE, Beyett TS, To C, Azevedo SC, Jang J, Bunnell T, Feru F, Li Z, Shin BH, Soroko KM, Gokhale PC, Gray NS, Jänne PA, Eck MJ, Scott DA. Gero TW, et al. Among authors: eck mj. Bioorg Med Chem Lett. 2022 Jul 15;68:128718. doi: 10.1016/j.bmcl.2022.128718. Epub 2022 Apr 1. Bioorg Med Chem Lett. 2022. PMID: 35378251 Free PMC article.
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.
To C, Beyett TS, Jang J, Feng WW, Bahcall M, Haikala HM, Shin BH, Heppner DE, Rana JK, Leeper BA, Soroko KM, Poitras MJ, Gokhale PC, Kobayashi Y, Wahid K, Kurppa KJ, Gero TW, Cameron MD, Ogino A, Mushajiang M, Xu C, Zhang Y, Scott DA, Eck MJ, Gray NS, Jänne PA. To C, et al. Among authors: eck mj. Nat Cancer. 2022 Apr;3(4):402-417. doi: 10.1038/s43018-022-00351-8. Epub 2022 Apr 14. Nat Cancer. 2022. PMID: 35422503 Free PMC article.
157 results