Eastman KJ - Search Results

1

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively.

Raina K, Forbes CD, Stronk R, Rappi JP Jr, Eastman KJ, Gerritz SW, Yu X, Li H, Bhardwaj A, Forgione M, Hundt A, King MP, Posner ZM, Denny A, McGovern A, Puleo DE, Garvin E, Chenard R, Zaware N, Mousseau JJ, Macaluso J, Martin M, Bassoli K, Jones K, Garcia M, Howard K, Smith LM, Chen JM, De Leon CA, Hines J, Kayser-Bricker KJ, Crews CM. Raina K, et al. Among authors: eastman kj. bioRxiv [Preprint]. 2023 Jan 2:2023.01.01.522436. doi: 10.1101/2023.01.01.522436. bioRxiv. 2023. PMID: 36711980 Free PMC article. Preprint.

2

Ferrocene-based inhibitors of hepatitis C virus replication that target NS5A with low picomolar in vitro antiviral activity.

Gadhachanda VR, Eastman KJ, Wang Q, Phadke AS, Patel D, Yang W, Marlor CW, Deshpande M, Huang M, Wiles JA. Gadhachanda VR, et al. Among authors: eastman kj. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3463-3471. doi: 10.1016/j.bmcl.2018.09.023. Epub 2018 Sep 18. Bioorg Med Chem Lett. 2018. PMID: 30290989

3

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.

Zhuo X, Wang YZ, Yeung KS, Zhu J, Huang XS, Parcella KE, Eastman KJ, Kadow JF, Meanwell NA, Shu YZ, Johnson BM. Zhuo X, et al. Among authors: eastman kj. Xenobiotica. 2018 Dec;48(12):1215-1226. doi: 10.1080/00498254.2017.1409915. Epub 2017 Dec 12. Xenobiotica. 2018. PMID: 29182424

4

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.

Eastman KJ, Parcella K, Yeung KS, Grant-Young KA, Zhu J, Wang T, Zhang Z, Yin Z, Beno BR, Sheriff S, Kish K, Tredup J, Jardel AG, Halan V, Ghosh K, Parker D, Mosure K, Fang H, Wang YK, Lemm J, Zhuo X, Hanumegowda U, Rigat K, Donoso M, Tuttle M, Zvyaga T, Haarhoff Z, Meanwell NA, Soars MG, Roberts SB, Kadow JF. Eastman KJ, et al. Medchemcomm. 2017 Feb 8;8(4):796-806. doi: 10.1039/c6md00636a. eCollection 2017 Apr 1. Medchemcomm. 2017. PMID: 30108798 Free PMC article.

5

Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.

Zhuo X, Cantone JL, Wang Y, Leet JE, Drexler DM, Yeung KS, Huang XS, Eastman KJ, Parcella KE, Mosure KW, Soars MG, Kadow JF, Johnson BM. Zhuo X, et al. Among authors: eastman kj. Drug Metab Dispos. 2016 Aug;44(8):1332-1340. doi: 10.1124/dmd.115.069062. Epub 2016 Mar 9. Drug Metab Dispos. 2016. PMID: 26961241

6

Applications of Fluorine in Medicinal Chemistry.

Gillis EP, Eastman KJ, Hill MD, Donnelly DJ, Meanwell NA. Gillis EP, et al. Among authors: eastman kj. J Med Chem. 2015 Nov 12;58(21):8315-59. doi: 10.1021/acs.jmedchem.5b00258. Epub 2015 Jul 22. J Med Chem. 2015. PMID: 26200936 Review.

7

Identification of a novel series of potent HCV NS5B Site I inhibitors.

Eastman KJ, Yang Z, Bender JA, Mosure K, Lemm JA, Meanwell NA, Roberts SB, Knipe J, Kadow JF. Eastman KJ, et al. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1993-7. doi: 10.1016/j.bmcl.2014.02.047. Epub 2014 Feb 28. Bioorg Med Chem Lett. 2014. PMID: 24656612

8

Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F.

Newhouse T, Lewis CA, Eastman KJ, Baran PS. Newhouse T, et al. Among authors: eastman kj. J Am Chem Soc. 2010 May 26;132(20):7119-37. doi: 10.1021/ja1009458. J Am Chem Soc. 2010. PMID: 20426477 Free PMC article.

9

Studies on the mechanism of action of prekinamycin, a member of the diazoparaquinone family of natural products: evidence for both sp2 radical and orthoquinonemethide intermediates.

Feldman KS, Eastman KJ. Feldman KS, et al. Among authors: eastman kj. J Am Chem Soc. 2006 Sep 27;128(38):12562-73. doi: 10.1021/ja0642616. J Am Chem Soc. 2006. PMID: 16984207 Free PMC article.

10

A proposal for the mechanism-of-action of diazoparaquinone natural products.

Feldman KS, Eastman KJ. Feldman KS, et al. Among authors: eastman kj. J Am Chem Soc. 2005 Nov 9;127(44):15344-5. doi: 10.1021/ja053880w. J Am Chem Soc. 2005. PMID: 16262378 Free PMC article.

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