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RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.
Cell Rep. 2018 Jul 24;24(4):1025-1036. doi: 10.1016/j.celrep.2018.06.105.
Cell Rep. 2018.
PMID: 30044970
Free PMC article.
Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.
Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA.
Knott GJ, et al. Among authors: east seletsky a.
Nat Struct Mol Biol. 2017 Oct;24(10):825-833. doi: 10.1038/nsmb.3466. Epub 2017 Sep 11.
Nat Struct Mol Biol. 2017.
PMID: 28892041
Free PMC article.
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RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.
East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA.
East-Seletsky A, et al.
Mol Cell. 2017 May 4;66(3):373-383.e3. doi: 10.1016/j.molcel.2017.04.008.
Mol Cell. 2017.
PMID: 28475872
Free PMC article.
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ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing.
Chen X, Shen Y, Draper W, Buenrostro JD, Litzenburger U, Cho SW, Satpathy AT, Carter AC, Ghosh RP, East-Seletsky A, Doudna JA, Greenleaf WJ, Liphardt JT, Chang HY.
Chen X, et al. Among authors: east seletsky a.
Nat Methods. 2016 Dec;13(12):1013-1020. doi: 10.1038/nmeth.4031. Epub 2016 Oct 17.
Nat Methods. 2016.
PMID: 27749837
Free PMC article.
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Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.
East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA.
East-Seletsky A, et al.
Nature. 2016 Oct 13;538(7624):270-273. doi: 10.1038/nature19802. Epub 2016 Sep 26.
Nature. 2016.
PMID: 27669025
Free PMC article.
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Identification of a Minimal Peptide Tag for in Vivo and in Vitro Loading of Encapsulin.
Cassidy-Amstutz C, Oltrogge L, Going CC, Lee A, Teng P, Quintanilla D, East-Seletsky A, Williams ER, Savage DF.
Cassidy-Amstutz C, et al. Among authors: east seletsky a.
Biochemistry. 2016 Jun 21;55(24):3461-8. doi: 10.1021/acs.biochem.6b00294. Epub 2016 Jun 7.
Biochemistry. 2016.
PMID: 27224728
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Programmable RNA recognition and cleavage by CRISPR/Cas9.
O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA.
O'Connell MR, et al. Among authors: east seletsky a.
Nature. 2014 Dec 11;516(7530):263-6. doi: 10.1038/nature13769. Epub 2014 Sep 28.
Nature. 2014.
PMID: 25274302
Free PMC article.
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Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Cowley GS, Weir BA, Vazquez F, Tamayo P, Scott JA, Rusin S, East-Seletsky A, Ali LD, Gerath WF, Pantel SE, Lizotte PH, Jiang G, Hsiao J, Tsherniak A, Dwinell E, Aoyama S, Okamoto M, Harrington W, Gelfand E, Green TM, Tomko MJ, Gopal S, Wong TC, Li H, Howell S, Stransky N, Liefeld T, Jang D, Bistline J, Hill Meyers B, Armstrong SA, Anderson KC, Stegmaier K, Reich M, Pellman D, Boehm JS, Mesirov JP, Golub TR, Root DE, Hahn WC.
Cowley GS, et al. Among authors: east seletsky a.
Sci Data. 2014 Sep 30;1:140035. doi: 10.1038/sdata.2014.35. eCollection 2014.
Sci Data. 2014.
PMID: 25984343
Free PMC article.
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