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Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F. Sanches M, et al. Among authors: durocher d. Nat Commun. 2014 Aug 28;5:4202. doi: 10.1038/ncomms5202. Nat Commun. 2014. PMID: 25164867 Free PMC article.
Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.
Gregorczyk M, Pastore G, Muñoz I, Carroll T, Streubel J, Munro M, Lis P, Lange S, Lamoliatte F, Macartney T, Toth R, Brown F, Hastie J, Pereira G, Durocher D, Rouse J. Gregorczyk M, et al. Among authors: durocher d. Life Sci Alliance. 2023 May 15;6(7):e202201740. doi: 10.26508/lsa.202201740. Print 2023 Jul. Life Sci Alliance. 2023. PMID: 37188479 Free PMC article.
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D. Nakada S, et al. Among authors: durocher d. Nature. 2010 Aug 19;466(7309):941-6. doi: 10.1038/nature09297. Nature. 2010. PMID: 20725033
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D. O'Donnell L, et al. Among authors: durocher d. Mol Cell. 2010 Nov 24;40(4):619-31. doi: 10.1016/j.molcel.2010.10.024. Epub 2010 Nov 4. Mol Cell. 2010. PMID: 21055983 Free PMC article.
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.
Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB. Volkmann K, et al. Among authors: durocher d. J Biol Chem. 2011 Apr 8;286(14):12743-55. doi: 10.1074/jbc.M110.199737. Epub 2011 Feb 8. J Biol Chem. 2011. PMID: 21303903 Free PMC article.
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F. Ceccarelli DF, et al. Among authors: durocher d. Cell. 2011 Jun 24;145(7):1075-87. doi: 10.1016/j.cell.2011.05.039. Epub 2011 Jun 16. Cell. 2011. PMID: 21683433 Free article.
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.
Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, Durocher D. Juang YC, et al. Among authors: durocher d. Mol Cell. 2012 Feb 10;45(3):384-97. doi: 10.1016/j.molcel.2012.01.011. Mol Cell. 2012. PMID: 22325355 Free PMC article.
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F. Wan LC, et al. Among authors: durocher d. Nucleic Acids Res. 2013 Jul;41(12):6332-46. doi: 10.1093/nar/gkt322. Epub 2013 Apr 25. Nucleic Acids Res. 2013. PMID: 23620299 Free PMC article.
133 results