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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
Manry J, Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Mégarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs CM, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau… See abstract for full author list ➔ Manry J, et al. Among authors: dupont a. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2200413119. doi: 10.1073/pnas.2200413119. Epub 2022 May 16. Proc Natl Acad Sci U S A. 2022. PMID: 35576468 Free PMC article.
Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19.
Duployez N, Demonchy J, Berthon C, Goutay J, Caplan M, Moreau AS, Bignon A, Marceau-Renaut A, Garrigue D, Raczkiewicz I, Geffroy S, Bucci M, Alidjinou K, Demaret J, Labalette M, Brousseau T, Dupont A, Rauch A, Poissy J, Susen S, Preudhomme C, Quesnel B. Duployez N, et al. Among authors: dupont a. Cancers (Basel). 2020 Jul 21;12(7):1992. doi: 10.3390/cancers12071992. Cancers (Basel). 2020. PMID: 32708264 Free PMC article.
Coagulation biomarkers are independent predictors of increased oxygen requirements in COVID-19.
Rauch A, Labreuche J, Lassalle F, Goutay J, Caplan M, Charbonnier L, Rohn A, Jeanpierre E, Dupont A, Duhamel A, Faure K, Lambert M, Kipnis E, Garrigue D, Lenting PJ, Poissy J, Susen S. Rauch A, et al. Among authors: dupont a. J Thromb Haemost. 2020 Nov;18(11):2942-2953. doi: 10.1111/jth.15067. Epub 2020 Sep 18. J Thromb Haemost. 2020. PMID: 32881304 Free PMC article.
Endotheliopathy Is Induced by Plasma From Critically Ill Patients and Associated With Organ Failure in Severe COVID-19.
Rauch A, Dupont A, Goutay J, Caplan M, Staessens S, Moussa M, Jeanpierre E, Corseaux D, Lefevre G, Lassalle F, Faure K, Lambert M, Duhamel A, Labreuche J, Garrigue D, De Meyer SF, Staels B, Van Belle E, Vincent F, Kipnis E, Lenting PJ, Poissy J, Susen S; Lille COVID Research Network (LICORNE); Members of the LICORNE Scientific Committee. Rauch A, et al. Among authors: dupont a. Circulation. 2020 Nov 10;142(19):1881-1884. doi: 10.1161/CIRCULATIONAHA.120.050907. Epub 2020 Sep 24. Circulation. 2020. PMID: 32970476 Free PMC article. No abstract available.
Severe SARS-CoV-2 patients develop a higher specific T-cell response.
Demaret J, Lefèvre G, Vuotto F, Trauet J, Duhamel A, Labreuche J, Varlet P, Dendooven A, Stabler S, Gachet B, Bauer J, Prevost B, Bocket L, Alidjinou EK, Lambert M, Yelnik C, Meresse B, Dubuquoy L, Launay D, Dubucquoi S, Montaigne D, Woitrain E, Maggiotto F, Bou Saleh M, Top I, Elsermans V, Jeanpierre E, Dupont A, Susen S, Brousseau T, Poissy J, Faure K, Labalette M; Lille Covid Research Network (LICORNE). Demaret J, et al. Among authors: dupont a. Clin Transl Immunology. 2020 Dec 23;9(12):e1217. doi: 10.1002/cti2.1217. eCollection 2020. Clin Transl Immunology. 2020. PMID: 33376594 Free PMC article.
Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19.
Dupont A, Rauch A, Staessens S, Moussa M, Rosa M, Corseaux D, Jeanpierre E, Goutay J, Caplan M, Varlet P, Lefevre G, Lassalle F, Bauters A, Faure K, Lambert M, Duhamel A, Labreuche J, Garrigue D, De Meyer SF, Staels B, Vincent F, Rousse N, Kipnis E, Lenting P, Poissy J, Susen S; Lille Covid Research Network (LICORNE). Dupont A, et al. Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1760-1773. doi: 10.1161/ATVBAHA.120.315595. Epub 2021 Feb 25. Arterioscler Thromb Vasc Biol. 2021. PMID: 33626910 Free article.
Pharmacokinetics of enoxaparin in COVID-19 critically ill patients.
Zufferey PJ, Dupont A, Lanoiselée J, Bauters A, Poissy J, Goutay J, Jean L, Caplan M, Levy L, Susen S, Delavenne X. Zufferey PJ, et al. Among authors: dupont a. Thromb Res. 2021 Sep;205:120-127. doi: 10.1016/j.thromres.2021.07.010. Epub 2021 Jul 21. Thromb Res. 2021. PMID: 34311154 Free PMC article.
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs C, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Coulibaly B, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Nussbaum RL, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, K… See abstract for full author list ➔ Bastard P, et al. Among authors: dupont a. Sci Immunol. 2021 Aug 19;6(62):eabl4340. doi: 10.1126/sciimmunol.abl4340. Sci Immunol. 2021. PMID: 34413139 Free PMC article.
1,108 results