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Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.
Needham EJ, Ren AL, Digby RJ, Norton EJ, Ebrahimi S, Outtrim JG, Chatfield DA, Manktelow AE, Leibowitz MM, Newcombe VFJ, Doffinger R, Barcenas-Morales G, Fonseca C, Taussig MJ, Burnstein RM, Samanta RJ, Dunai C, Sithole N, Ashton NJ, Zetterberg H, Gisslén M, Edén A, Marklund E, Openshaw PJM, Dunning J, Griffiths MJ, Cavanagh J, Breen G, Irani SR, Elmer A, Kingston N, Summers C, Bradley JR, Taams LS, Michael BD, Bullmore ET, Smith KGC, Lyons PA, Coles AJ, Menon DK; Cambridge NeuroCOVID Group; CITIID-NIHR COVID-19 BioResource Collaboration; Cambridge NIHR Clinical Research Facility. Needham EJ, et al. Among authors: dunning j. Brain. 2022 Nov 21;145(11):4097-4107. doi: 10.1093/brain/awac321. Brain. 2022. PMID: 36065116 Free PMC article.
Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus.
Habibi MS, Jozwik A, Makris S, Dunning J, Paras A, DeVincenzo JP, de Haan CA, Wrammert J, Openshaw PJ, Chiu C; Mechanisms of Severe Acute Influenza Consortium Investigators. Habibi MS, et al. Among authors: dunning j. Am J Respir Crit Care Med. 2015 May 1;191(9):1040-9. doi: 10.1164/rccm.201412-2256OC. Am J Respir Crit Care Med. 2015. PMID: 25730467 Free PMC article. Clinical Trial.
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites RS, Sanchez Sevilla Uruchurtu A, Siggins MK, Liew F, Russell CD, Moore SC, Fairfield C, Carter E, Abrams S, Short CE, Thaventhiran T, Bergstrom E, Gardener Z, Ascough S, Chiu C, Docherty AB, Hunt D, Crow YJ, Solomon T, Taylor GP, Turtle L, Harrison EM, Dunning J, Semple MG, Baillie JK, Openshaw PJ; ISARIC4C investigators. Thwaites RS, et al. Among authors: dunning j. Sci Immunol. 2021 Mar 10;6(57):eabg9873. doi: 10.1126/sciimmunol.abg9873. Sci Immunol. 2021. PMID: 33692097 Free PMC article.
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study.
Drake TM, Riad AM, Fairfield CJ, Egan C, Knight SR, Pius R, Hardwick HE, Norman L, Shaw CA, McLean KA, Thompson AAR, Ho A, Swann OV, Sullivan M, Soares F, Holden KA, Merson L, Plotkin D, Sigfrid L, de Silva TI, Girvan M, Jackson C, Russell CD, Dunning J, Solomon T, Carson G, Olliaro P, Nguyen-Van-Tam JS, Turtle L, Docherty AB, Openshaw PJ, Baillie JK, Harrison EM, Semple MG; ISARIC4C investigators. Drake TM, et al. Among authors: dunning j. Lancet. 2021 Jul 17;398(10296):223-237. doi: 10.1016/S0140-6736(21)00799-6. Lancet. 2021. PMID: 34274064 Free PMC article.
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study.
Hurst EA, Mellanby RJ, Handel I, Griffith DM, Rossi AG, Walsh TS, Shankar-Hari M, Dunning J, Homer NZ, Denham SG, Devine K, Holloway PA, Moore SC, Thwaites RS, Samanta RJ, Summers C, Hardwick HE, Oosthuyzen W, Turtle L, Semple MG, Openshaw PJM, Baillie JK, Russell CD; ISARIC4C Investigators. Hurst EA, et al. Among authors: dunning j. BMJ Open. 2021 Oct 22;11(10):e055435. doi: 10.1136/bmjopen-2021-055435. BMJ Open. 2021. PMID: 34686560 Free PMC article.
Obesity dysregulates the pulmonary antiviral immune response.
Almond M, Farne HA, Jackson MM, Jha A, Katsoulis O, Pitts O, Tunstall T, Regis E, Dunning J, Byrne AJ, Mallia P, Kon OM, Saunders KA, Simpson KD, Snelgrove RJ, Openshaw PJM, Edwards MR, Barclay WS, Heaney LM, Johnston SL, Singanayagam A. Almond M, et al. Among authors: dunning j. Nat Commun. 2023 Oct 19;14(1):6607. doi: 10.1038/s41467-023-42432-x. Nat Commun. 2023. PMID: 37857661 Free PMC article.
M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.
Cole SL, Dunning J, Kok WL, Benam KH, Benlahrech A, Repapi E, Martinez FO, Drumright L, Powell TJ, Bennett M, Elderfield R, Thomas C; MOSAIC investigators; Dong T, McCauley J, Liew FY, Taylor S, Zambon M, Barclay W, Cerundolo V, Openshaw PJ, McMichael AJ, Ho LP. Cole SL, et al. Among authors: dunning j. JCI Insight. 2017 Apr 6;2(7):e91868. doi: 10.1172/jci.insight.91868. JCI Insight. 2017. PMID: 28405622 Free PMC article.
762 results