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Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, Jean-Gilles D, Clark R, Atchison K, Moore R, Chibnik LB, Tanzi RE, Frosch MP, Serrano-Pozo A, Elwood F, Steen JA, Kennedy ME, Hyman BT. Dujardin S, et al. Nat Med. 2020 Aug;26(8):1256-1263. doi: 10.1038/s41591-020-0938-9. Epub 2020 Jun 22. Nat Med. 2020. PMID: 32572268 Free PMC article.
Enhanced Tau Aggregation in the Presence of Amyloid β.
Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT. Bennett RE, et al. Among authors: dujardin s. Am J Pathol. 2017 Jul;187(7):1601-1612. doi: 10.1016/j.ajpath.2017.03.011. Epub 2017 May 10. Am J Pathol. 2017. PMID: 28500862 Free PMC article.
What is the evidence that tau pathology spreads through prion-like propagation?
Mudher A, Colin M, Dujardin S, Medina M, Dewachter I, Alavi Naini SM, Mandelkow EM, Mandelkow E, Buée L, Goedert M, Brion JP. Mudher A, et al. Among authors: dujardin s. Acta Neuropathol Commun. 2017 Dec 19;5(1):99. doi: 10.1186/s40478-017-0488-7. Acta Neuropathol Commun. 2017. PMID: 29258615 Free PMC article. Review.
Tau protein liquid-liquid phase separation can initiate tau aggregation.
Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT. Wegmann S, et al. Among authors: dujardin s. EMBO J. 2018 Apr 3;37(7):e98049. doi: 10.15252/embj.201798049. Epub 2018 Feb 22. EMBO J. 2018. PMID: 29472250 Free PMC article.
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. Eftekharzadeh B, et al. Among authors: dujardin s. Neuron. 2018 Sep 5;99(5):925-940.e7. doi: 10.1016/j.neuron.2018.07.039. Neuron. 2018. PMID: 30189209 Free PMC article.
Different tau species lead to heterogeneous tau pathology propagation and misfolding.
Dujardin S, Bégard S, Caillierez R, Lachaud C, Carrier S, Lieger S, Gonzalez JA, Deramecourt V, Déglon N, Maurage CA, Frosch MP, Hyman BT, Colin M, Buée L. Dujardin S, et al. Acta Neuropathol Commun. 2018 Nov 29;6(1):132. doi: 10.1186/s40478-018-0637-7. Acta Neuropathol Commun. 2018. PMID: 30497516 Free PMC article.
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. Eftekharzadeh B, et al. Among authors: dujardin s. Neuron. 2019 Jan 16;101(2):349. doi: 10.1016/j.neuron.2018.12.031. Neuron. 2019. PMID: 30653936 Free PMC article. No abstract available.
65 results