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IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model.
Lutz V, Hellmund VM, Picard FSR, Raifer H, Ruckenbrod T, Klein M, Bopp T, Savai R, Duewell P, Keber CU, Weigert A, Chung HR, Buchholz M, Menke A, Gress TM, Huber M, Bauer C. Lutz V, et al. Among authors: duewell p. Cancer Immunol Res. 2023 Apr 3;11(4):421-434. doi: 10.1158/2326-6066.CIR-22-0398. Cancer Immunol Res. 2023. PMID: 36758176
Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8(+) T-cell and B-cell responses but improves clinical efficacy in a murine pancreatic carcinoma model.
Bauer C, Sterzik A, Bauernfeind F, Duewell P, Conrad C, Kiefl R, Endres S, Eigler A, Schnurr M, Dauer M. Bauer C, et al. Among authors: duewell p. Cancer Immunol Immunother. 2014 Apr;63(4):321-33. doi: 10.1007/s00262-013-1510-y. Epub 2014 Jan 3. Cancer Immunol Immunother. 2014. PMID: 24384835 Free PMC article.
Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut.
Mak'Anyengo R, Duewell P, Reichl C, Hörth C, Lehr HA, Fischer S, Clavel T, Denk G, Hohenester S, Kobold S, Endres S, Schnurr M, Bauer C. Mak'Anyengo R, et al. Among authors: duewell p. JCI Insight. 2018 Mar 8;3(5):e96322. doi: 10.1172/jci.insight.96322. JCI Insight. 2018. PMID: 29515025 Free PMC article.
Strategies to relieve immunosuppression in pancreatic cancer.
Schnurr M, Duewell P, Bauer C, Rothenfusser S, Lauber K, Endres S, Kobold S. Schnurr M, et al. Among authors: duewell p. Immunotherapy. 2015;7(4):363-76. doi: 10.2217/imt.15.9. Immunotherapy. 2015. PMID: 25917628 Review.
Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model.
Metzger P, Kirchleitner SV, Boehmer DFR, Hörth C, Eisele A, Ormanns S, Gunzer M, Lech M, Lauber K, Endres S, Duewell P, Schnurr M, König LM. Metzger P, et al. Among authors: duewell p. Cancer Immunol Immunother. 2020 Oct;69(10):2101-2112. doi: 10.1007/s00262-020-02605-9. Epub 2020 May 24. Cancer Immunol Immunother. 2020. PMID: 32448983 Free PMC article.
35 results