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Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity.
Bury M, Novo-Uzal E, Andolfi A, Cimini S, Wauthoz N, Heffeter P, Lallemand B, Avolio F, Delporte C, Cimmino A, Dubois J, Van Antwerpen P, Zonno MC, Vurro M, Poumay Y, Berger W, Evidente A, De Gara L, Kiss R, Locato V. Bury M, et al. Among authors: dubois j. Int J Oncol. 2013 Aug;43(2):575-85. doi: 10.3892/ijo.2013.1979. Epub 2013 Jun 10. Int J Oncol. 2013. PMID: 23754298
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
Lamoral-Theys D, Andolfi A, Van Goietsenoven G, Cimmino A, Le Calvé B, Wauthoz N, Mégalizzi V, Gras T, Bruyère C, Dubois J, Mathieu V, Kornienko A, Kiss R, Evidente A. Lamoral-Theys D, et al. Among authors: dubois j. J Med Chem. 2009 Oct 22;52(20):6244-56. doi: 10.1021/jm901031h. J Med Chem. 2009. PMID: 19788245 Free PMC article.
Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.
Lamoral-Theys D, Pottier L, Kerff F, Dufrasne F, Proutière F, Wauthoz N, Neven P, Ingrassia L, Antwerpen PV, Lefranc F, Gelbcke M, Pirotte B, Kraus JL, Nève J, Kornienko A, Kiss R, Dubois J. Lamoral-Theys D, et al. Among authors: dubois j. Bioorg Med Chem. 2010 Jun 1;18(11):3823-33. doi: 10.1016/j.bmc.2010.04.047. Epub 2010 Apr 21. Bioorg Med Chem. 2010. PMID: 20466556 Free PMC article.
Trivanillic polyphenols with anticancer cytostatic effects through the targeting of multiple kinases and intracellular Ca2+ release.
Lamoral-Theys D, Wauthoz N, Heffeter P, Mathieu V, Jungwirth U, Lefranc F, Nève J, Dubois J, Dufrasne F, Amighi K, Berger W, Gailly P, Kiss R. Lamoral-Theys D, et al. Among authors: dubois j. J Cell Mol Med. 2012 Jul;16(7):1421-34. doi: 10.1111/j.1582-4934.2011.01403.x. J Cell Mol Med. 2012. PMID: 21810170 Free PMC article.
1,939 results