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Prolonged activity of the transposase helper may raise safety concerns during DNA transposon-based gene therapy.
Mol Ther Methods Clin Dev. 2023 Mar 14;29:145-159. doi: 10.1016/j.omtm.2023.03.003. eCollection 2023 Jun 8.
Mol Ther Methods Clin Dev. 2023.
PMID: 37025950
Free PMC article.
A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver.
Kopasz AG, Pusztai DZ, Karkas R, Hudoba L, Abdullah KSA, Imre G, Pankotai-Bodó G, Migh E, Nagy A, Kriston A, Germán P, Drubi AB, Molnár A, Fekete I, Dani VÉ, Ocsovszki I, Puskás LG, Horváth P, Sükösd F, Mátés L.
Kopasz AG, et al. Among authors: drubi ab.
BMC Biol. 2022 Apr 1;20(1):74. doi: 10.1186/s12915-022-01262-x.
BMC Biol. 2022.
PMID: 35361222
Free PMC article.
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