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Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.
Abraham SA, Hopcroft LE, Carrick E, Drotar ME, Dunn K, Williamson AJ, Korfi K, Baquero P, Park LE, Scott MT, Pellicano F, Pierce A, Copland M, Nourse C, Grimmond SM, Vetrie D, Whetton AD, Holyoake TL. Abraham SA, et al. Among authors: drotar me. Nature. 2016 Jun 16;534(7607):341-6. doi: 10.1038/nature18288. Epub 2016 Jun 8. Nature. 2016. PMID: 27281222 Free PMC article.
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.
Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LE, Kinstrie R, Guitart AV, Dunn K, Abraham SA, Sansom O, Michie AM, Machesky L, Kranc KR, Graham GJ, Pellicano F, Holyoake TL. Sinclair A, et al. Blood. 2016 Jul 21;128(3):371-83. doi: 10.1182/blood-2015-08-661785. Epub 2016 May 24. Blood. 2016. PMID: 27222476 Free PMC article.
Senescent cells harbour features of the cancer epigenome.
Cruickshanks HA, McBryan T, Nelson DM, Vanderkraats ND, Shah PP, van Tuyn J, Singh Rai T, Brock C, Donahue G, Dunican DS, Drotar ME, Meehan RR, Edwards JR, Berger SL, Adams PD. Cruickshanks HA, et al. Among authors: drotar me. Nat Cell Biol. 2013 Dec;15(12):1495-506. doi: 10.1038/ncb2879. Epub 2013 Nov 24. Nat Cell Biol. 2013. PMID: 24270890 Free PMC article.
Wnt signaling potentiates nevogenesis.
Pawlikowski JS, McBryan T, van Tuyn J, Drotar ME, Hewitt RN, Maier AB, King A, Blyth K, Wu H, Adams PD. Pawlikowski JS, et al. Among authors: drotar me. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16009-14. doi: 10.1073/pnas.1303491110. Epub 2013 Sep 16. Proc Natl Acad Sci U S A. 2013. PMID: 24043806 Free PMC article.
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.
Rai TS, Cole JJ, Nelson DM, Dikovskaya D, Faller WJ, Vizioli MG, Hewitt RN, Anannya O, McBryan T, Manoharan I, van Tuyn J, Morrice N, Pchelintsev NA, Ivanov A, Brock C, Drotar ME, Nixon C, Clark W, Sansom OJ, Anderson KI, King A, Blyth K, Adams PD. Rai TS, et al. Among authors: drotar me. Genes Dev. 2014 Dec 15;28(24):2712-25. doi: 10.1101/gad.247528.114. Genes Dev. 2014. PMID: 25512559 Free PMC article.
12 results