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Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models.
Kaiser FK, Hernandez MG, Krüger N, Englund E, Du W, Mykytyn AZ, Raadsen MP, Lamers MM, Rodrigues Ianiski F, Shamorkina TM, Snijder J, Armando F, Beythien G, Ciurkiewicz M, Schreiner T, Gruber-Dujardin E, Bleyer M, Batura O, Erffmeier L, Hinkel R, Rocha C, Mirolo M, Drabek D, Bosch BJ, Emalfarb M, Valbuena N, Tchelet R, Baumgärtner W, Saloheimo M, Pöhlmann S, Grosveld F, Haagmans BL, Osterhaus ADME. Kaiser FK, et al. Among authors: drabek d. Nat Commun. 2024 Mar 14;15(1):2319. doi: 10.1038/s41467-024-46443-0. Nat Commun. 2024. PMID: 38485931 Free PMC article.
A human monoclonal antibody blocking SARS-CoV-2 infection.
Wang C, Li W, Drabek D, Okba NMA, van Haperen R, Osterhaus ADME, van Kuppeveld FJM, Haagmans BL, Grosveld F, Bosch BJ. Wang C, et al. Among authors: drabek d. Nat Commun. 2020 May 4;11(1):2251. doi: 10.1038/s41467-020-16256-y. Nat Commun. 2020. PMID: 32366817 Free PMC article.
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies.
Wang C, van Haperen R, Gutiérrez-Álvarez J, Li W, Okba NMA, Albulescu I, Widjaja I, van Dieren B, Fernandez-Delgado R, Sola I, Hurdiss DL, Daramola O, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ. Wang C, et al. Among authors: drabek d. Nat Commun. 2021 Mar 17;12(1):1715. doi: 10.1038/s41467-021-21968-w. Nat Commun. 2021. PMID: 33731724 Free PMC article.
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern.
Du W, Hurdiss DL, Drabek D, Mykytyn AZ, Kaiser FK, González-Hernández M, Muñoz-Santos D, Lamers MM, van Haperen R, Li W, Drulyte I, Wang C, Sola I, Armando F, Beythien G, Ciurkiewicz M, Baumgärtner W, Guilfoyle K, Smits T, van der Lee J, van Kuppeveld FJM, van Amerongen G, Haagmans BL, Enjuanes L, Osterhaus ADME, Grosveld F, Bosch BJ. Du W, et al. Among authors: drabek d. Sci Immunol. 2022 Jul 29;7(73):eabp9312. doi: 10.1126/sciimmunol.abp9312. Epub 2022 Jul 29. Sci Immunol. 2022. PMID: 35471062 Free PMC article.
Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants.
Du W, Janssens R, Mykytyn AZ, Li W, Drabek D, van Haperen R, Chatziandreou M, Rissmann M, van der Lee J, van Dortmondt M, Martin IS, van Kuppeveld FJM, Hurdiss DL, Haagmans BL, Grosveld F, Bosch BJ. Du W, et al. Among authors: drabek d. Front Immunol. 2023 Feb 21;14:1111385. doi: 10.3389/fimmu.2023.1111385. eCollection 2023. Front Immunol. 2023. PMID: 36895554 Free PMC article.
SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster Model.
Haagmans BL, Noack D, Okba NMA, Li W, Wang C, Bestebroer T, de Vries R, Herfst S, de Meulder D, Verveer E, van Run P, Lamers MM, Rijnders B, Rokx C, van Kuppeveld F, Grosveld F, Drabek D, Geurts van Kessel C, Koopmans M, Bosch BJ, Kuiken T, Rockx B. Haagmans BL, et al. Among authors: drabek d. J Infect Dis. 2021 Jun 15;223(12):2020-2028. doi: 10.1093/infdis/jiab289. J Infect Dis. 2021. PMID: 34043806 Free PMC article.
Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.
Widjaja I, Wang C, van Haperen R, Gutiérrez-Álvarez J, van Dieren B, Okba NMA, Raj VS, Li W, Fernandez-Delgado R, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ. Widjaja I, et al. Among authors: drabek d. Emerg Microbes Infect. 2019;8(1):516-530. doi: 10.1080/22221751.2019.1597644. Emerg Microbes Infect. 2019. PMID: 30938227 Free PMC article.
Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection.
Stalin Raj V, Okba NMA, Gutierrez-Alvarez J, Drabek D, van Dieren B, Widagdo W, Lamers MM, Widjaja I, Fernandez-Delgado R, Sola I, Bensaid A, Koopmans MP, Segalés J, Osterhaus ADME, Bosch BJ, Enjuanes L, Haagmans BL. Stalin Raj V, et al. Among authors: drabek d. Sci Adv. 2018 Aug 8;4(8):eaas9667. doi: 10.1126/sciadv.aas9667. eCollection 2018 Aug. Sci Adv. 2018. PMID: 30101189 Free PMC article.
42 results