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Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies.
Bezençon O, Siegrist R, Heidmann B, Pozzi D, Stamm S, Remeň L, Richard S, Simons L, Gaston R, Downing D, Grisostomi C, Roch C, Kessler M, Gatfield J, Moon R, Pfeifer T, Mosbacher J, Reymond I, Ertel EA, de Kanter R, Capeleto B, Fournier E, Rey M, Moccia L, Toeroek-Schafroth M, Roscher R, Schindelholz B. Bezençon O, et al. Among authors: downing d. Chimia (Aarau). 2017 Oct 25;71(10):722-729. doi: 10.2533/chimia.2017.722. Chimia (Aarau). 2017. PMID: 29070417 Free article.
Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent.
Wright JL, Downing DM, Feng MR, Hayes RN, Heffner TG, MacKenzie RG, Meltzer LT, Pugsley TA, Wise LD. Wright JL, et al. Among authors: downing dm. J Med Chem. 1995 Dec 22;38(26):5007-14. doi: 10.1021/jm00026a007. J Med Chem. 1995. PMID: 8544176
Discovery of novel non-peptidic ketopiperazine-based renin inhibitors.
Holsworth DD, Powell NA, Downing DM, Cai C, Cody WL, Ryan JM, Ostroski R, Jalaie M, Bryant JW, Edmunds JJ. Holsworth DD, et al. Among authors: downing dm. Bioorg Med Chem. 2005 Apr 1;13(7):2657-64. doi: 10.1016/j.bmc.2005.01.048. Bioorg Med Chem. 2005. PMID: 15755665
Ketopiperazine-based renin inhibitors: optimization of the "C" ring.
Holsworth DD, Cai C, Cheng XM, Cody WL, Downing DM, Erasga N, Lee C, Powell NA, Edmunds JJ, Stier M, Jalaie M, Zhang E, McConnell P, Ryan MJ, Bryant J, Li T, Kasani A, Hall E, Subedi R, Rahim M, Maiti S. Holsworth DD, et al. Among authors: downing dm. Bioorg Med Chem Lett. 2006 May 1;16(9):2500-4. doi: 10.1016/j.bmcl.2006.01.084. Epub 2006 Feb 15. Bioorg Med Chem Lett. 2006. PMID: 16480874
Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones.
Galatsis P, Caprathe B, Downing D, Gilmore J, Harter W, Hays S, Kostlan C, Linn K, Lunney E, Para K, Thomas A, Warmus J, Allen H, Brady K, Talanian R, Walker N. Galatsis P, et al. Among authors: downing d. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5089-94. doi: 10.1016/j.bmcl.2010.07.031. Epub 2010 Jul 11. Bioorg Med Chem Lett. 2010. PMID: 20674352
The association between mental health stigma and face emotion recognition in individuals at risk for psychosis.
Herrera SN, Larsen EM, Deluca JS, Crump FM, Grivel M, Blasco D, Bryant C, Shapiro DI, Downing D, Girgis RR, Brucato G, Huang D, Kufert Y, Verdi M, West ML, Seidman LJ, Link BG, McFarlane WR, Woodberry KA, Yang LH, Corcoran CM. Herrera SN, et al. Among authors: downing d. Stigma Health. 2023 Feb;8(1):31-39. doi: 10.1037/sah0000379. Epub 2022 Apr 21. Stigma Health. 2023. PMID: 36968262 Free PMC article.
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